Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.42 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 4/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | STAT1 | P42224 | 1/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | ESR1 | P03372 | 1/20 | 0.35 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.35 |
| ▸ | ELANE | P08246 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10785167 | 0.85 | SMN1; SMN2 (0.47) | L3MBTL1GAACHRNB2CHRNA4SMN1; SMN2 | |
| SCHEMBL8404289 | 0.85 | SMN1; SMN2 (0.47) | L3MBTL1GAACHRNB2CHRNA4SMN1; SMN2 | |
| SCHEMBL2756560 | 0.80 | L3MBTL1 (0.53) | L3MBTL1GAACHRNB2CHRNA4SMN1; SMN2 | |
| SCHEMBL24133258 | 0.78 | LMNA (0.36) | RAB9ANPC1ESR1ESR2LMNA | |
| SCHEMBL9912823 | 0.78 | L3MBTL1 (0.52) | L3MBTL1GAACHRNB2CHRNA4SMN1; SMN2 | |
| SCHEMBL17988076 | 0.77 | LRRK2 (0.45) | L3MBTL1GAACHRNB2CHRNA4SMN1; SMN2 | |
| SCHEMBL25995484 | 0.77 | L3MBTL1 (0.38) | L3MBTL1GAACHRNB2CHRNA4SMN1; SMN2 | |
| SCHEMBL19914259 | 0.76 | LRRK2 (0.44) | L3MBTL1GAACHRNB2CHRNA4SMN1; SMN2 | |
| SCHEMBL3180303 | 0.75 | GAA (0.46) | L3MBTL1GAACHRNB2CHRNA4SMN1; SMN2 | |
| SCHEMBL3822917 | 0.74 | SMN1; SMN2 (0.48) | L3MBTL1GAACHRNB2CHRNA4SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230019280-A1 | SUBSTITUTED ISOINDOLONYL 2,2'-BIPYRIMIDINYL COMPOUNDS, ANALOGUES THEREOF, AND METHODS USING SAME | ARBUTUS BIOPHARMA CORPORATION (CA) | 2023-01-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230019280-A1 | SUBSTITUTED ISOINDOLONYL 2,2'-BIPYRIMIDINYL COMPOUNDS, ANALOGUES THEREOF, AND METHODS USING SAME | HAVCR2, CDV3, HCCS | L3MBTL1 1428/4885GAA 3490/4885CHRNB2 4846/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.