SCHEMBL2491316

SCHEMBL2491316

CCc1nc(N)c(C(=O)O)[nH]1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 1/20 0.41
ALDH1A1 P00352 1/20 0.41
HPGD P15428 1/20 0.41
HTT P42858 1/20 0.41
RECQL P46063 1/20 0.41
GABRP O00591 2/20 0.36
GABRD O14764 2/20 0.36
GABRA1 P14867 2/20 0.36
GABRB1 P18505 2/20 0.36
GABRG2 P18507 2/20 0.36
GABRB3 P28472 2/20 0.36
GABRA5 P31644 2/20 0.36
GABRA3 P34903 2/20 0.36
GABRA2 P47869 2/20 0.36
GABRB2 P47870 2/20 0.36
GABRA4 P48169 2/20 0.36
GABRE P78334 2/20 0.36
GABRA6 Q16445 2/20 0.36
GABRG1 Q8N1C3 2/20 0.36
GABRG3 Q99928 2/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2778487 0.78 TP53 (0.44) ALDH1A1ADORA3ADORA2AADORA1TNKS2
SCHEMBL2804373 0.78 PIN1 (0.44) KDM4EADORA3ADORA2AADORA1TNKS2
SCHEMBL3034374 0.77 GAA (0.37) HTTADORA3ADORA2AADORA1
SCHEMBL8542685 0.73 GPR35 (0.34) ADORA3ADORA2AADORA1TNKS2LMNA
Hydrochloric Acid SCHEMBL9847453 0.71 CDK1 (0.36) KDM4EALDH1A1HPGDHTTRECQL
SCHEMBL13056606 0.71 ADORA3 (0.36) KDM4EALDH1A1HPGDHTTRECQL
SCHEMBL4802255 0.70 SMN1; SMN2 (0.49) KDM4EALDH1A1HPGDADORA3ADORA2A
SCHEMBL7234563 0.70 ALDH1A1 (0.39) KDM4EALDH1A1HPGDHTTRECQL
SCHEMBL27609241 0.70 ALDH1A1 (0.39) KDM4EALDH1A1HPGDHTTRECQL
SCHEMBL9283238 0.70 GABRP (0.38) KDM4EGABRPGABRDGABRA1GABRB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2177606-A2 N-deoxyribosyltransferases from lactobacillus, corresponding nucleotide sequences and their applications INSTITUT PASTEUR (FR) 2010-04-21 EP claimed
EP-1427819-B1 LACTOBACILLUS N-DEOXYRIBOSYL TRANSFERASES, CORRESPONDING NUCLEOTIDE SEQUENCES AND THEIR USES PASTEUR INSTITUT (FR) 2009-12-23 EP claimed
US-20080280329-A1 Enzymatic synthesis of deoxyribonucleosides TISCHER WILHELM 2008-11-13 US claimed
US-20080250513-A1 LACTOBACILLUS N-DEOXYRIBOSYL TRANSFERASES, CORRESPONDING NUCLEOTIDE SEQUENCES AND THEIR USES INSTITUT PASTEUR (FR) 2008-10-09 US claimed
US-20060068473-A1 Lactobacillus N-deoxyribosyl transferases, corresponding nucleotide sequences and their uses INSTITUT PASTEUR (FR) 2006-03-30 US claimed
EP-1427819-A2 LACTOBACILLUS N-DEOXYRIBOSYL TRANSFERASES, CORRESPONDING NUCLEOTIDE SEQUENCES AND THEIR USES INSTITUT PASTEUR (FR) 2004-06-16 EP claimed
WO-2003025163-A2 LACTOBACILLUS N-DEOXYRIBOSYL TRANSFERASES, CORRESPONDING NUCLEOTIDE SEQUENCES AND THEIR USES INSTITUT PASTEUR (FR) 2003-03-27 WO claimed
EP-1206551-A2 ENZYMATIC SYNTHESIS OF DEOXYRIBONUCLEOSIDES Roche Diagnostics GmbH (DE) 2002-05-22 EP claimed
WO-2001014566-A2 ENZYMATIC SYNTHESIS OF DEOXYRIBONUCLEOSIDES ROCHE DIAGNOSTICS GMBH (DE) 2001-03-01 WO claimed
EP-1206551-B2 ENZYMATIC SYNTHESIS OF DEOXYRIBONUCLEOSIDES PASTEUR INSTITUT (FR) 2011-10-26 EP disclosed
EP-2177606-A2 N-deoxyribosyltransferases from lactobacillus, corresponding nucleotide sequences and their applications INSTITUT PASTEUR (FR) 2010-04-21 EP disclosed
US-20100015685-A1 LACTOBACILLUS N-DEOXYRIBOSYL TRANSFERASES, CORRESPONDING NUCLEOTIDE SEQUENCES AND THEIR USES INSTITUT PASTEUR (FR) 2010-01-21 US disclosed
EP-1427819-B1 LACTOBACILLUS N-DEOXYRIBOSYL TRANSFERASES, CORRESPONDING NUCLEOTIDE SEQUENCES AND THEIR USES PASTEUR INSTITUT (FR) 2009-12-23 EP disclosed
EP-1206551-B1 ENZYMATIC SYNTHESIS OF DEOXYRIBONUCLEOSIDES PASTEUR INSTITUT (FR) 2009-05-13 EP disclosed
WO-2003025163-A2 LACTOBACILLUS N-DEOXYRIBOSYL TRANSFERASES, CORRESPONDING NUCLEOTIDE SEQUENCES AND THEIR USES INSTITUT PASTEUR (FR) 2003-03-27 WO disclosed
EP-1206551-A2 ENZYMATIC SYNTHESIS OF DEOXYRIBONUCLEOSIDES Roche Diagnostics GmbH (DE) 2002-05-22 EP disclosed
WO-2001014566-A2 ENZYMATIC SYNTHESIS OF DEOXYRIBONUCLEOSIDES ROCHE DIAGNOSTICS GMBH (DE) 2001-03-01 WO disclosed
US-4766110-A INHIBITS ANGIOTENSIN CONVERTING ENZYME, HYPOTENSIVE AGENTS RYAN JAMES W (US) 1988-08-23 US disclosed
EP-0073143-B1 NOVEL COMPLEX AMIDO AND IMIDO DERIVATIVES OF CARBOXYALKYL PEPTIDES AND THIOETHERS AND ETHERS OF PEPTIDES Ryan, James Walter (US) 1985-11-21 EP disclosed
EP-0073143-A2 Novel complex amido and imido derivatives of carboxyalkyl peptides and thioethers and ethers of peptides Ryan, James Walter (US) 1983-03-02 EP disclosed