Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.35 |
| ▸ | GDA | Q9Y2T3 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | BACE1 | P56817 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | PI4KA | P42356 | 1/20 | 0.33 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.33 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.33 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.33 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.33 |
| ▸ | IKBKB | O14920 | 2/20 | 0.32 |
| ▸ | GPR84 | Q9NQS5 | 5/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27609241 | 0.86 | ALDH1A1 (0.39) | ALDH1A1KDM4EHPGDHTTRECQL | |
| SCHEMBL5990880 | 0.82 | MAPK1 (0.39) | ALDH1A1KDM4EHPGDHTTRECQL | |
| SCHEMBL30296121 | 0.82 | POLB (0.38) | ALDH1A1KDM4EGLAPDPK1POLB | |
| SCHEMBL9199916 | 0.81 | HPGD (0.46) | ALDH1A1KDM4EHPGDHTTRECQL | |
| SCHEMBL9137641 | 0.80 | ALDH1A1 (0.65) | ALDH1A1KDM4EHPGDHTTRECQL | |
| SCHEMBL27344634 | 0.74 | GLA (0.31) | GLAPOLB | |
| SCHEMBL2298861 | 0.72 | PI4KA (0.41) | ALDH1A1KDM4ERECQLGLAPOLB | |
| SCHEMBL9283238 | 0.71 | GABRP (0.38) | KDM4EGLAPOLBUSP2TSHR | |
| SCHEMBL11471657 | 0.71 | GLA (0.36) | ALDH1A1KDM4EGLAPOLBBACE1 | |
| SCHEMBL1079587 | 0.71 | GLA (0.36) | ALDH1A1KDM4EGLAPOLBBACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030073834-A1 | Purine compounds having PDE IV inhibitory activity and methods of synthesis | CAVALLA DAVID J (GB) | 2003-04-17 | — | — | US | disclosed |
| US-20020028469-A1 | Method of defining genus of chemical compound and method of designing molecules | BURCH RONALD M (US) | 2002-03-07 | — | — | US | disclosed |
| EP-1045850-A4 | PURINE COMPOUNDS HAVING PDE IV INHIBITORY ACTIVITY AND METHODS OF SYNTHESIS | EURO CELTIQUE SA (LU) | 2001-10-31 | — | — | EP | disclosed |
| US-6211367-B1 | REACTING AN 2-IMIDAZOLINE COMPOUND WITH A BENZALDEHYDE; REDUCTION | EURO-CELTIQUE, S.A. (LU) | 2001-04-03 | — | — | US | disclosed |
| CN-1281458-A | Purine compounds having PDE IV inhibitory activity and methods of synthesis | EURO CELTIQUE SA (LU) | 2001-01-24 | — | — | CN | disclosed |
| EP-1045850-A1 | PURINE COMPOUNDS HAVING PDE IV INHIBITORY ACTIVITY AND METHODS OF SYNTHESIS | Euro-Celtique S.A. (LU) | 2000-10-25 | — | — | EP | disclosed |
| WO-1999029694-A1 | PURINE COMPOUNDS HAVING PDE IV INHIBITORY ACTIVITY AND METHODS OF SYNTHESIS | EURO-CELTIQUE, S.A. (LU) | 1999-06-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030073834-A1 | Purine compounds having PDE IV inhibitory activity and methods of synthesis | PDE3B, PDE3A, PDE4A | ALDH1A1 487/4885KDM4E 1278/4885HPGD 846/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.