Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.42 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.40 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.40 |
| ▸ | XDH | P47989 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.36 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | PYGL | P06737 | 1/20 | 0.35 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2491534 | 0.80 | LOXL2 (0.44) | LOXL2MTNR1AMTNR1BXDHKDM4E | |
| SCHEMBL853696 | 0.78 | MTNR1A (0.50) | LOXL2MTNR1AMTNR1BXDHKDM4E | |
| SCHEMBL11827124 | 0.76 | KDM4E (0.51) | KDM4EALDH1A1LMNAHPGDPYGL | |
| SCHEMBL5159413 | 0.74 | ADAMTS4 (0.54) | LOXL2MTNR1AMTNR1BKDM4ELMNA | |
| SCHEMBL12831625 | 0.71 | MTNR1A (0.43) | LOXL2MTNR1AMTNR1BXDHKDM4E | |
| SCHEMBL27195633 | 0.71 | LOXL2 (0.57) | LOXL2MTNR1AMTNR1BXDHKDM4E | |
| SCHEMBL30880119 | 0.71 | LOXL2 (0.57) | LOXL2MTNR1AMTNR1BXDHKDM4E | |
| SCHEMBL7973131 | 0.69 | PDGFRB (0.56) | LOXL2MTNR1AMTNR1BXDHKDM4E | |
| SCHEMBL852358 | 0.69 | ITGB3 (0.61) | — | |
| SCHEMBL3828574 | 0.69 | LOXL2 (0.58) | LOXL2MTNR1AMTNR1BKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1425010-B1 | SUBSTITUTED INDOLES AND THEIR USE AS INTEGRIN ANTAGONISTS | ORTHO MCNEIL PHARM INC (US) | 2011-10-26 | — | — | EP | disclosed |