Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.57 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | CES2 | O00748 | 2/20 | 0.42 |
| ▸ | CES1 | P23141 | 2/20 | 0.42 |
| ▸ | BCHE | P06276 | 1/20 | 0.42 |
| ▸ | KRAS | P01116 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | ALB | P02768 | 1/20 | 0.40 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.40 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.40 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.40 |
| ▸ | HCRTR2 | O43614 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | LCLAT1 | Q6UWP7 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30214455 | 0.88 | ALDH1A1 (0.52) | ALDH1A1ALOX15KMT2ANPC1SMN1; SMN2 | |
| SCHEMBL699716 | 0.86 | ALDH1A1 (0.45) | ALDH1A1ALOX15KMT2ANPC1SMN1; SMN2 | |
| SCHEMBL28266600 | 0.85 | CES2 (0.45) | ALDH1A1ALOX15KMT2ANPC1SMN1; SMN2 | |
| SCHEMBL184046 | 0.83 | ALB (0.55) | ALDH1A1ALOX15KMT2ANPC1SMN1; SMN2 | |
| SCHEMBL29933044 | 0.83 | ALB (0.55) | ALDH1A1ALOX15KMT2ANPC1SMN1; SMN2 | |
| SCHEMBL1261333 | 0.83 | KMT2A (0.50) | ALDH1A1ALOX15KMT2ANPC1SMN1; SMN2 | |
| SCHEMBL3383096 | 0.82 | ALDH1A1 (0.53) | ALDH1A1ALOX15KMT2ASMN1; SMN2CES2 | |
| SCHEMBL528652 | 0.81 | LMNA (0.43) | ALDH1A1KMT2ANPC1SMN1; SMN2CES2 | |
| SCHEMBL5444249 | 0.81 | TSHR (0.48) | ALDH1A1KMT2ANPC1SMN1; SMN2RAB9A | |
| SCHEMBL7666396 | 0.81 | ALDH1A1 (0.49) | ALDH1A1ALOX15KMT2ANPC1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110483423-A | P2X4 receptor antagonist | NIPPON CHEMIPHAR CO | 2019-11-22 | — | — | CN | disclosed |
| CN-110300579-A | Sulfamoyl aryl derivatives and its purposes for being used to treat liver fibrosis as drug | 詹森药业有限公司 | 2019-10-01 | — | — | CN | disclosed |
| US-10385060-B2 | Piperidine derivative and preparation method and pharmaceutical use thereof | JIANGSU HENGRUI MEDICINE CO., LTD. (CN) | 2019-08-20 | — | — | US | disclosed |
| CN-107406457-B | Piperidine derivative, preparation method and medical application thereof | 江苏恒瑞医药股份有限公司 | 2019-02-01 | — | — | CN | disclosed |
| CN-108863959-A | P2X4 RECEPTOR ANTAGONIST | 日本化学药品株式会社 | 2018-11-23 | — | — | CN | disclosed |
| US-20180298020-A1 | Piperidine Derivative and Preparation Method and Pharmaceutical Use Thereof | SHANGHAI HENGRUI PHARMACEUTICAL CO., LTD. (CN) | 2018-10-18 | — | — | US | disclosed |
| US-10087191-B2 | Piperidine derivative and preparation method and pharmaceutical use thereof | JIANGSU HENGRUI MEDICINE CO., LTD. (CN) | 2018-10-02 | — | — | US | disclosed |
| CN-108473481-A | compounds useful as kinase inhibitors | 洛克索肿瘤学股份有限公司 | 2018-08-31 | — | — | CN | disclosed |
| CN-108431007-A | PYRAZOLOPYRIMIDINE DERIVATIVES AS BTK INHIBITORS FOR THE TREATMENT OF CANCER | 洛克索肿瘤学股份有限公司 | 2018-08-21 | — | — | CN | disclosed |
| US-20180170943-A1 | PIPERIDINE DERIVATIVE AND PREPARATION METHOD AND PHARMACEUTICAL USE THEREOF | JIANGSU HENGRUI MEDICINE CO., LTD. (CN) | 2018-06-21 | — | — | US | disclosed |
| WO-2006066070-A2 | PRODRUG CONSTRUCTS OF PYRIMIDINONE COMPOUNDS AS CALCILYTICS | NPS PHARMACEUTICALS, INC. (US) | 2006-06-22 | — | — | WO | disclosed |
| CN-1656061-A | Organic compounds | NOVARTIS AG (CH) | 2005-08-17 | — | — | CN | disclosed |
| CN-1602296-A | Amidoacetonitrile derivatives | NOVARTIS AG (CH) | 2005-03-30 | — | — | CN | disclosed |
| EP-0266980-B1 | PHARMACEUTICAL COMPOSITIONS, COMPRISING A 2,4-DIPHENYL-1,3-DIOXANE DERIVATIVE AND AN INHIBITOR OF THROMBOXANE A2 SYNTHESIS | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1992-10-28 | — | — | EP | disclosed |
| EP-0201354-B1 | 2,4-DIPHENYL-1,3-DIOXANES | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1990-09-19 | — | — | EP | disclosed |
| US-4908380-A | Substituted 1,3-dioxane ether derivative; thromboxane A2 inhibitor | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1990-03-13 | — | — | US | disclosed |
| US-4895962-A | THROMBOXANE A2 ANTAGONISTS | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1990-01-23 | — | — | US | disclosed |
| US-4775685-A | THROMBOXANE A-2 ANTAGONISTS | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1988-10-04 | — | — | US | disclosed |
| EP-0266980-A2 | Pharmaceutical compositions, comprising a 2,4-diphenyl-1,3-dioxane derivative and an inhibitor of thromboxane A2 synthesis | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1988-05-11 | — | — | EP | disclosed |
| EP-0201354-A2 | 2,4-Diphenyl-1,3-Dioxanes | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1986-11-12 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10385060-B2 | Piperidine derivative and preparation method and pharmaceutical use thereof | GPER1, CYP19A1, PGR | ALDH1A1 195/4885ALOX15 1572/4885KMT2A 1991/4885 |
| US-10087191-B2 | Piperidine derivative and preparation method and pharmaceutical use thereof | GPER1, CYP19A1, PGR | ALDH1A1 195/4885ALOX15 1572/4885KMT2A 1991/4885 |
| US-20180170943-A1 | PIPERIDINE DERIVATIVE AND PREPARATION METHOD AND PHARMACEUTICAL USE THEREOF | GPER1, CYP19A1, PGR | ALDH1A1 195/4885ALOX15 1572/4885KMT2A 1991/4885 |
| US-20180298020-A1 | Piperidine Derivative and Preparation Method and Pharmaceutical Use Thereof | GPER1, CYP19A1, PGR | ALDH1A1 195/4885ALOX15 1572/4885KMT2A 1991/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.