Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.47 |
| ▸ | CFTR | P13569 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3511611 | 0.86 | TSHR (0.57) | TSHRLMNAALDH1A1KMT2ASLC6A3 | |
| SCHEMBL28266600 | 0.85 | CES2 (0.45) | ALDH1A1KMT2ANPC1SMN1; SMN2POLB | |
| SCHEMBL1341386 | 0.84 | KMT2A (0.50) | TSHRALDH1A1KMT2ASLC6A4SLC6A3 | |
| SCHEMBL1261333 | 0.83 | KMT2A (0.50) | LMNAALDH1A1KMT2ANPC1SMN1; SMN2 | |
| SCHEMBL184046 | 0.83 | ALB (0.55) | ALDH1A1KMT2AHSD17B10NPC1SMN1; SMN2 | |
| SCHEMBL29933044 | 0.83 | ALB (0.55) | ALDH1A1KMT2AHSD17B10NPC1SMN1; SMN2 | |
| SCHEMBL12492132 | 0.83 | ALDH1A1 (0.47) | TSHRLMNAALDH1A1KMT2ASLC6A4 | |
| SCHEMBL28289327 | 0.83 | KMT2A (0.39) | ALDH1A1KMT2AHSD17B10NPC1SMN1; SMN2 | |
| SCHEMBL27471522 | 0.82 | KMT2A (0.48) | LMNAALDH1A1KMT2ANPC1SMN1; SMN2 | |
| SCHEMBL28829625 | 0.82 | TDP1 (0.52) | TSHRLMNAALDH1A1KMT2ASLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110141570-A | Medical compounds | 西雅图遗传学公司 | 2019-08-20 | — | — | CN | disclosed |
| CN-110143950-A | Medical compounds | 西雅图遗传学公司 | 2019-08-20 | — | — | CN | disclosed |
| CN-106170288-B | Pharmaceutical compounds | 西雅图遗传学公司 | 2019-07-19 | — | — | CN | disclosed |
| US-9783522-B2 | 2-amino-pyridine and 2-amino-pyrimidine derivatives and medicinal use thereof | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2017-10-10 | — | — | US | disclosed |
| US-9783522-B2 | 2-amino-pyridine and 2-amino-pyrimidine derivatives and medicinal use thereof | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2017-10-10 | — | — | US | disclosed |
| US-20170044133-A1 | NOVEL 2-AMINO-PYRIDINE AND 2-AMINO-PYRIMIDINE DERIVATIVES AND MEDICINAL USE THEREOF | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2017-02-16 | — | — | US | disclosed |
| US-20170044133-A1 | NOVEL 2-AMINO-PYRIDINE AND 2-AMINO-PYRIMIDINE DERIVATIVES AND MEDICINAL USE THEREOF | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2017-02-16 | — | — | US | disclosed |
| CN-104853757-A | 4-heteroaryl substituted benzoic acid compounds as ROR gamma T inhibitors and uses thereof | MERCK SHARP & DOHME | 2015-08-19 | — | — | CN | disclosed |
| CN-104822377-A | N-alkylated indole and indazole compounds as ROR gamma T inhibitors and uses thereof | MERCK SHARP & DOHME | 2015-08-05 | — | — | CN | disclosed |
| US-20090137557-A1 | Calcilytic Compounds | SMITHKLINE BEECHAM CORPORATION | 2009-05-28 | — | — | US | disclosed |
| US-20070270446-A1 | Reversed Pyrimidinone Compounds as Calcilytics | SMITHKLINE BEECHAM CORPORATION (US) | 2007-11-22 | — | — | US | disclosed |
| EP-1809611-A1 | REVERSED PYRIMIDINONE COMPOUNDS AS CALCILYTICS | NPS PHARMACEUTICALS, INC. (US) | 2007-07-25 | — | — | EP | disclosed |
| WO-2006041968-A1 | REVERSED PYRIMIDINONE COMPOUNDS AS CALCILYTICS | NPS PHARMACEUTICALS, INC. (US) | 2006-04-20 | — | — | WO | disclosed |
| EP-0266980-B1 | PHARMACEUTICAL COMPOSITIONS, COMPRISING A 2,4-DIPHENYL-1,3-DIOXANE DERIVATIVE AND AN INHIBITOR OF THROMBOXANE A2 SYNTHESIS | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1992-10-28 | — | — | EP | disclosed |
| EP-0201354-B1 | 2,4-DIPHENYL-1,3-DIOXANES | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1990-09-19 | — | — | EP | disclosed |
| US-4908380-A | Substituted 1,3-dioxane ether derivative; thromboxane A2 inhibitor | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1990-03-13 | — | — | US | disclosed |
| US-4895962-A | THROMBOXANE A2 ANTAGONISTS | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1990-01-23 | — | — | US | disclosed |
| US-4775685-A | THROMBOXANE A-2 ANTAGONISTS | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1988-10-04 | — | — | US | disclosed |
| EP-0266980-A2 | Pharmaceutical compositions, comprising a 2,4-diphenyl-1,3-dioxane derivative and an inhibitor of thromboxane A2 synthesis | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1988-05-11 | — | — | EP | disclosed |
| EP-0201354-A2 | 2,4-Diphenyl-1,3-Dioxanes | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1986-11-12 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070270446-A1 | Reversed Pyrimidinone Compounds as Calcilytics | PTMS, CALCR, TYMP | TSHR 2935/4885LMNA 845/4885ALDH1A1 3806/4885 |
| US-20170044133-A1 | NOVEL 2-AMINO-PYRIDINE AND 2-AMINO-PYRIMIDINE DERIVATIVES AND MEDICINAL USE THEREOF | ENPP2, ATXN2, ATXN2L | TSHR 2255/4885LMNA 2206/4885ALDH1A1 3768/4885 |
| US-20090137557-A1 | Calcilytic Compounds | CALCR, SOST, CALCB | TSHR 3409/4885LMNA 1316/4885ALDH1A1 4674/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.