Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 2/20 | 0.32 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.31 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.31 |
| ▸ | PRKACA | P17612 | 1/20 | 0.31 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.31 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.31 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.31 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.31 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.31 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.31 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.31 |
| ▸ | CCR1 | P32246 | 1/20 | 0.31 |
| ▸ | CCR5 | P51681 | 1/20 | 0.31 |
| ▸ | CCR8 | P51685 | 1/20 | 0.31 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24920809 | 0.81 | PDE10A (0.34) | — | |
| SCHEMBL24920821 | 0.76 | KDM4E (0.43) | ALDH1A1NOTUM | |
| SCHEMBL24920393 | 0.72 | CCR1 (0.53) | HCRTR1HCRTR2ROCK1DYRK1ACLK4 | |
| SCHEMBL24920899 | 0.71 | TDO2 (0.36) | — | |
| SCHEMBL24920389 | 0.69 | GABRG2 (0.38) | HCRTR1HCRTR2ALDH1A1 | |
| SCHEMBL14982162 | 0.69 | ADRB1 (0.51) | — | |
| SCHEMBL24921192 | 0.68 | CHRNB2 (0.49) | ROCK2MAP4K4PRKACAROCK1DYRK1A | |
| SCHEMBL20912238 | 0.68 | EGLN1 (0.39) | HCRTR1HCRTR2ALDH1A1CLK4CCR1 | |
| SCHEMBL2614481 | 0.67 | — | — | |
| SCHEMBL19480834 | 0.67 | HCRTR1 (0.37) | HCRTR1HCRTR2ALDH1A1ROCK2MAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023006097-A1 | BIFUNCTIONAL CHIMERIC HETEROCYCLIC COMPOUND AND USE THEREOF AS ANDROGEN RECEPTOR DEGRADER | 海创药业股份有限公司 | 2023-02-02 | — | — | WO | disclosed |