SCHEMBL249501

SCHEMBL249501

CCCNC(=N)NC(F)(F)F

nearest known ligand 0.35

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
KDM4C Q9H3R0 1/20 0.35
MEN1 O00255 1/20 0.33
KMT2A Q03164 1/20 0.33
EPHX1 P07099 2/20 0.31
MMP1 P03956 1/20 0.31
MMP2 P08253 1/20 0.31
MMP3 P08254 1/20 0.31
MMP9 P14780 1/20 0.31
ALDH1A1 P00352 1/20 0.31
POLB P06746 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13959065 0.79 KDM4C (0.41) KDM4CMEN1KMT2AEPHX1MMP1
SCHEMBL1273741 0.77 MMP1 (0.40) KDM4CKMT2AEPHX1MMP1MMP2
SCHEMBL13943361 0.72 MMP1 (0.37) KDM4CKMT2AEPHX1MMP1MMP2
SCHEMBL4100814 0.70
SCHEMBL564253 0.70
SCHEMBL13973081 0.70
SCHEMBL14997799 0.70 KDM4C (0.37) KDM4C
SCHEMBL15228190 0.69
SCHEMBL10446327 0.69
SCHEMBL16309335 0.69 EPHX1 (0.48) MEN1KMT2AEPHX1MMP1MMP2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 196 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2008157537-A2 COMPOSITIONS AND METHODS OF USE FOR TREATING OR PREVENTING LIPID RELATED DISORDERS IRONWOOD PHARMACEUTICALS, INC (US) 2008-12-24 WO claimed
WO-2008124505-A2 SOLUBLE GUANYLATE CYCLASE (SGC) MODULATORS FOR TREATMENT OF LIPID RELATED DISORDERS IRONWOOD PHARMACEUTICALS,INC. (US) 2008-10-16 WO claimed
US-20260116886-A1 DEUTERATED sGC STIMULATORS TISENTO THERAPEUTICS INC (US) 2026-04-30 US disclosed
US-20260000653-A1 TREATMENT OF CNS DISEASES WITH sGC STIMULATORS TISENTO THERAPEUTICS INC (US) 2026-01-01 US disclosed
US-20250326761-A1 sGC STIMULATORS TISENTO THERAPEUTICS INC (US) 2025-10-23 US disclosed
EP-4605394-A1 PYRIMIDINE SGC STIMULATORS Tisento Therapeutics Inc. (US) 2025-08-27 EP disclosed
EP-4605080-A1 TREATMENT OF MITOCHONDRIAL DISEASES WITH SGC STIMULATORS Tisento Therapeutics Inc. (US) 2025-08-27 EP disclosed
US-20250243177-A1 sGC STIMULATORS CYCLERION THERAPEUTICS, INC. 2025-07-31 US disclosed
US-20250243228-A1 PHOSPHORUS PRODRUGS OF PYRAZOLO-SUBSTITUTED PYRIMIDINE sGC STIMULATORS CYCLERION THERAPEUTICS, INC. 2025-07-31 US disclosed
US-20250243205-A1 sGC STIMULATORS TISENTO THERAPEUTICS INC (US) 2025-07-31 US disclosed
US-20250129060-A1 SOLID FORMS OF AN SGC STIMULATOR CYCLERION THERAPEUTICS INC (US) 2025-04-24 US disclosed
WO-2012003405-A1 SGC STIMULATORS IRONWOOD PHARMACEUTICALS, INC. (US) 2012-01-05 WO disclosed
WO-2011115804-A1 SGC STIMULATORS IRONWOOD PHARMACEUTICALS, INC. (US) 2011-09-22 WO disclosed
US-20110160225-A1 COMPOSITIONS AND METHODS OF USE FOR TREATING OR PREVENTING LIPID RELATED DISORDERS IRONWOOD PHARMACEUTICALS, INC. (US) 2011-06-30 US disclosed
US-20100144864-A1 SOLUBLE GUANYLATE CYCLASE (SGC) MODULATORS FOR TREATMENT OF LIPID RELATED DISORDERS IRONWOOD PHARMACEUTICALS, INC. (US) 2010-06-10 US disclosed
EP-2152266-A1 COMPOSITIONS AND METHODS FOR TREATING DISORDERS ASSOCIATED WITH SALT OR FLUID RETENTION Ironwood Pharmaceuticals, Inc. (US) 2010-02-17 EP disclosed
US-20090054450-A1 COMPOSITIONS AND METHODS OF USE FOR TREATING OR PREVENTING LIPID RELATED DISORDERS IRONWOOD PHARMACEUTICALS, INC. (US) 2009-02-26 US disclosed
WO-2008157537-A2 COMPOSITIONS AND METHODS OF USE FOR TREATING OR PREVENTING LIPID RELATED DISORDERS IRONWOOD PHARMACEUTICALS, INC (US) 2008-12-24 WO disclosed
WO-2008137318-A1 COMPOSITIONS AND METHODS FOR TREATING DISORDERS ASSOCIATED WITH SALT OR FLUID RETENTION IRONWOOD PHARMACEUTICALS, INC. (US) 2008-11-13 WO disclosed
WO-2008124505-A2 SOLUBLE GUANYLATE CYCLASE (SGC) MODULATORS FOR TREATMENT OF LIPID RELATED DISORDERS IRONWOOD PHARMACEUTICALS,INC. (US) 2008-10-16 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100144864-A1 SOLUBLE GUANYLATE CYCLASE (SGC) MODULATORS FOR TREATMENT OF LIPID RELATED DISORDERS GUCY1A2, GUCY1B2, GUCY1B1 KDM4C 4177/4885MEN1 3134/4885KMT2A 3747/4885
US-20250326761-A1 sGC STIMULATORS GUCY1A2, PRKG1, GMPS KDM4C 4348/4885MEN1 4282/4885KMT2A 4533/4885
US-20110160225-A1 COMPOSITIONS AND METHODS OF USE FOR TREATING OR PREVENTING LIPID RELATED DISORDERS LIPC, PNLIP, LIPA KDM4C 2521/4885MEN1 3036/4885KMT2A 3307/4885
US-20250243228-A1 PHOSPHORUS PRODRUGS OF PYRAZOLO-SUBSTITUTED PYRIMIDINE sGC STIMULATORS P2RY1, P2RY11, GMPS KDM4C 3389/4885MEN1 2462/4885KMT2A 3926/4885
US-20250129060-A1 SOLID FORMS OF AN SGC STIMULATOR GUCY1A2, PRKG1, GUCY1A1 KDM4C 4103/4885MEN1 2814/4885KMT2A 4402/4885
US-20260116886-A1 DEUTERATED sGC STIMULATORS PDE2A, PRKG1, GUCY1A2 KDM4C 3169/4885MEN1 3027/4885KMT2A 4127/4885
US-20090054450-A1 COMPOSITIONS AND METHODS OF USE FOR TREATING OR PREVENTING LIPID RELATED DISORDERS LIPC, PNLIP, LIPA KDM4C 2521/4885MEN1 3036/4885KMT2A 3307/4885
US-20260000653-A1 TREATMENT OF CNS DISEASES WITH sGC STIMULATORS PDE9A, PDE2A, GUCY1A2 KDM4C 4155/4885MEN1 1173/4885KMT2A 4514/4885
US-20250243177-A1 sGC STIMULATORS GUCY1A1, PTGIS, GUCY1B1 KDM4C 3857/4885MEN1 3461/4885KMT2A 4149/4885
US-20250243205-A1 sGC STIMULATORS GMPS, GUCY1A2, PDE2A KDM4C 4101/4885MEN1 3842/4885KMT2A 4604/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.