Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 3/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | CDK8 | P49336 | 2/20 | 0.45 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.45 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.45 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.45 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.43 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.43 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.43 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.43 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.41 |
| ▸ | VEGFA | P15692 | 1/20 | 0.40 |
| ▸ | FLT1 | P17948 | 1/20 | 0.40 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.40 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.40 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.39 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30851237 | 0.90 | NR1H2 (0.48) | SYKCDK8PIK3CDPIK3CGPIK3CA | |
| SCHEMBL24967930 | 0.90 | NR1H2 (0.48) | SYKCDK8PIK3CDPIK3CGPIK3CA | |
| SCHEMBL24967940 | 0.78 | HSD17B1 (0.52) | SYKPIK3CDPIK3CGPIK3CAPIK3CB | |
| SCHEMBL30851292 | 0.78 | HSD17B1 (0.52) | SYKPIK3CDPIK3CGPIK3CAPIK3CB | |
| SCHEMBL24967932 | 0.77 | PIK3CD (0.48) | SYKLMNACDK8PIK3CDPIK3CG | |
| SCHEMBL30165044 | 0.77 | PIK3CD (0.48) | SYKLMNACDK8PIK3CDPIK3CG | |
| SCHEMBL21915788 | 0.76 | LMNA (0.50) | SYKLMNANR1H2NR1H3POLB | |
| SCHEMBL6270689 | 0.75 | AGXT (0.56) | SYKNR1H2NR1H3POLBSLC7A5 | |
| SCHEMBL3933089 | 0.74 | ALDH1A1 (0.60) | SYKCYP11B1CYP11B2SLC7A5KDM4E | |
| SCHEMBL3930818 | 0.74 | MAP4K4 (0.57) | SYKCYP11B1CYP11B2CYP4F2CYP4A11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117642393-A | Novel PARP7 inhibitor and application thereof | 上海齐鲁制药研究中心有限公司 | 2024-03-01 | — | — | CN | disclosed |
| WO-2023006013-A1 | NOVEL PARP7 INHIBITOR AND USE THEREOF | 上海齐鲁制药研究中心有限公司 | 2023-02-02 | — | — | WO | disclosed |