SCHEMBL2497590

SCHEMBL2497590

C=CCn1c(SC)cc2ccccc21

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 1/20 0.43
PARP1 P09874 1/20 0.43
KDM4E B2RXH2 6/20 0.41
PKM P14618 2/20 0.41
POLB P06746 1/20 0.41
NPSR1 Q6W5P4 1/20 0.41
GAA P10253 1/20 0.41
RAB9A P51151 3/20 0.39
ALDH1A1 P00352 6/20 0.39
HPGD P15428 4/20 0.39
MAPT P10636 5/20 0.39
L3MBTL1 Q9Y468 2/20 0.39
TDP1 Q9NUW8 1/20 0.39
SMN1; SMN2 Q16637 2/20 0.38
TSHR P16473 2/20 0.38
HSD17B10 Q99714 2/20 0.38
TP53 P04637 1/20 0.38
HTT P42858 1/20 0.38
CYP1A2 P05177 1/20 0.38
CYP3A4 P08684 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6428552 0.78 PARP1 (0.48) LMNAPARP1KDM4EPKMPOLB
SCHEMBL31219282 0.78 PARP1 (0.48) LMNAPARP1KDM4EPKMPOLB
SCHEMBL663628 0.76 LMNA (0.44) LMNAPARP1KDM4EPKMPOLB
SCHEMBL28147782 0.75 LMNA (0.43) LMNAPARP1KDM4EPKMPOLB
SCHEMBL28147868 0.75 MTNR1A (0.44) LMNAPARP1KDM4EPKMPOLB
SCHEMBL11667512 0.73 LMNA (0.42) LMNAPARP1KDM4EPKMPOLB
SCHEMBL16487399 0.73 CCR2 (0.48) LMNAKDM4EPOLBNPSR1RAB9A
SCHEMBL14387230 0.72 LMNA (0.41) LMNAPARP1KDM4EPKMPOLB
SCHEMBL31185729 0.72 L3MBTL1 (0.58) PARP1KDM4ENPSR1ALDH1A1HPGD
SCHEMBL14246881 0.72 L3MBTL1 (0.58) PARP1KDM4ENPSR1ALDH1A1HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2003171-B1 CYANINE COMPOUND AND OPTICAL RECORDING MATERIAL ADEKA CORP (JP) 2014-09-03 EP disclosed
EP-2371905-B1 Cyanine compound and optical recording material ADEKA CORP (JP) 2013-03-06 EP disclosed
US-8206806-B2 Cyanine compound and optical recording material ADEKA CORPORATION (JP) 2012-06-26 US disclosed
EP-2371905-A1 Cyanine compound and optical recording material Adeka Corporation (JP) 2011-10-05 EP disclosed
EP-2003171-A9 CYANINE COMPOUND AND OPTICAL RECORDING MATERIAL Adeka Corporation (JP) 2009-04-22 EP disclosed
US-20090054652-A1 Cyanine Compound and Optical Recording Material ADEKA CORPORATION (JP) 2009-02-26 US disclosed
EP-2003171-A2 CYANINE COMPOUND AND OPTICAL RECORDING MATERIAL Adeka Corporation (JP) 2008-12-17 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090054652-A1 Cyanine Compound and Optical Recording Material CRY2, KCNQ5, KCNQ3 LMNA 1753/4885PARP1 553/4885KDM4E 1242/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.