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Sugi Predict / Compounds / SCHEMBL24977253

SCHEMBL24977253

SCHEMBL24977253

COC(=O)C(CO)c1ccccc1OCCO[Si](C)(C)C(C)(C)C

nearest known ligand 0.38

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
▸ GLS O94925 2/20 0.38
▸ ALDH1A1 P00352 5/20 0.36
▸ PPARG P37231 3/20 0.35
▸ NPSR1 Q6W5P4 1/20 0.35
▸ BTN3A1 O00481 1/20 0.35
▸ LMNA P02545 4/20 0.34
▸ SMN1; SMN2 Q16637 1/20 0.34
▸ L3MBTL1 Q9Y468 2/20 0.33
▸ MAPT P10636 2/20 0.33
▸ PPARA Q07869 1/20 0.33
▸ KDM4E B2RXH2 1/20 0.33
▸ GAA P10253 1/20 0.33
▸ TDP1 Q9NUW8 1/20 0.33
▸ MTNR1A P48039 1/20 0.33
▸ MTNR1B P49286 1/20 0.33
▸ POLB P06746 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24977860 0.88 ALDH1A1 (0.37) GLSALDH1A1PPARGLMNASMN1; SMN2
SCHEMBL24978136 0.82 KDM4E (0.42) GLSALDH1A1PPARGNPSR1LMNA
SCHEMBL25500765 0.80 PPARG (0.46) GLSALDH1A1PPARGLMNASMN1; SMN2
SCHEMBL24864131 0.79 TDP1 (0.42) ALDH1A1PPARGNPSR1LMNASMN1; SMN2
SCHEMBL13577114 0.77 ADRB2 (0.38) ALDH1A1NPSR1LMNASMN1; SMN2L3MBTL1
SCHEMBL24977254 0.73 PPARD (0.42) GLSALDH1A1PPARGNPSR1LMNA
SCHEMBL24810046 0.73 KMT2A (0.44) GLSBTN3A1LMNAL3MBTL1
SCHEMBL22396770 0.72 L3MBTL1 (0.54) ALDH1A1LMNASMN1; SMN2L3MBTL1MAPT
SCHEMBL30689715 0.72 ALDH1A1 (0.60) ALDH1A1NPSR1LMNASMN1; SMN2MAPT
SCHEMBL12634742 0.72 PPARG (0.41) ALDH1A1PPARGNPSR1LMNASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230151016-A1 PYRROLIDINE-PYRAZOLES AS PYRUVATE KINASE ACTIVATORS GLOBAL BLOOD THERAPEUTICS INC (US) 2023-05-18 — — US disclosed
US-20230151016-A1 PYRROLIDINE-PYRAZOLES AS PYRUVATE KINASE ACTIVATORS GLOBAL BLOOD THERAPEUTICS INC (US) 2023-05-18 — — US disclosed
US-11566030-B2 Substituted 2,6-dihydropyrrolo[3,4-c]pyrazoles as pyruvate kinase activators GLOBAL BLOOD THERAPEUTICS, INC. (US) 2023-01-31 — — US disclosed
US-11566030-B2 Substituted 2,6-dihydropyrrolo[3,4-c]pyrazoles as pyruvate kinase activators GLOBAL BLOOD THERAPEUTICS, INC. (US) 2023-01-31 — — US disclosed
US-20220267337-A1 PYRROLIDINE-PYRAZOLES AS PYRUVATE KINASE ACTIVATORS GLOBAL BLOOD THERAPEUTICS, INC. 2022-08-25 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11566030-B2 Substituted 2,6-dihydropyrrolo[3,4-c]pyrazoles as pyruvate kinase activators PDK1, PDK2, PDK3 GLS 206/4885ALDH1A1 1703/4885PPARG 337/4885
US-20220267337-A1 PYRROLIDINE-PYRAZOLES AS PYRUVATE KINASE ACTIVATORS PDK1, PDK2, PKM GLS 139/4885ALDH1A1 1784/4885PPARG 341/4885
US-20230151016-A1 PYRROLIDINE-PYRAZOLES AS PYRUVATE KINASE ACTIVATORS PDK1, PDK2, PKM GLS 139/4885ALDH1A1 1784/4885PPARG 341/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.