Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | ACACB | O00763 | 2/20 | 0.46 |
| ▸ | XDH | P47989 | 1/20 | 0.46 |
| ▸ | CHRNB2 | P17787 | 5/20 | 0.45 |
| ▸ | CHRNA4 | P43681 | 5/20 | 0.45 |
| ▸ | RAB9A | P51151 | 4/20 | 0.45 |
| ▸ | CHRNB4 | P30926 | 4/20 | 0.45 |
| ▸ | CHRNA3 | P32297 | 4/20 | 0.45 |
| ▸ | NPC1 | O15118 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.44 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.44 |
| ▸ | ACACA | Q13085 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25003134 | 0.95 | NPC1 (0.51) | KMT2AMEN1RAB9ANPC1KDM4E | |
| SCHEMBL25003126 | 0.90 | ALDH1A1 (0.51) | PLK1KMT2AMEN1ACACBXDH | |
| SCHEMBL25002912 | 0.86 | PLA2G2A (0.48) | PLK1KMT2AMEN1ACACBXDH | |
| SCHEMBL25003826 | 0.85 | CA1 (0.54) | KMT2AMEN1RAB9ANPC1KDM4E | |
| SCHEMBL25003142 | 0.82 | ALDH1A1 (0.53) | KMT2AMEN1ACACBXDHRAB9A | |
| SCHEMBL25002892 | 0.81 | NPC1 (0.52) | KMT2AMEN1RAB9ANPC1KDM4E | |
| SCHEMBL25003153 | 0.80 | KMT2A (0.48) | KMT2AMEN1RAB9ANPC1KDM4E | |
| SCHEMBL25003806 | 0.80 | ALDH1A1 (0.48) | PLK1CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL25003131 | 0.78 | MAP4K4 (0.55) | KMT2AMEN1XDHRAB9AKDM4E | |
| SCHEMBL6538458 | 0.78 | PLK1 (0.69) | PLK1KMT2AMEN1XDHCHRNB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023010192-A1 | N-ACYLHYDRAZONE COMPOUNDS CAPABLE OF INHIBITING NAV1.7 AND/OR NAV1.8, PROCESSES FOR THE PREPARATION THEREOF, COMPOSITIONS, USES, METHODS FOR TREATMENT USING SAME, AND KITS | EUROFARMA LABORATÓRIOS S.A. (BR) | 2023-02-09 | — | — | WO | disclosed |