Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 1/20 | 0.54 |
| ▸ | CA2 | P00918 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 4/20 | 0.52 |
| ▸ | NPC1 | O15118 | 4/20 | 0.52 |
| ▸ | MEN1 | O00255 | 4/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.52 |
| ▸ | CLK4 | Q9HAZ1 | 5/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | CLK1 | P49759 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25003126 | 0.88 | ALDH1A1 (0.51) | MAPTNPC1MEN1KMT2AALDH1A1 | |
| SCHEMBL25003134 | 0.85 | NPC1 (0.51) | MAPTNPC1MEN1KMT2AALDH1A1 | |
| SCHEMBL25003142 | 0.85 | ALDH1A1 (0.53) | MAPTNPC1MEN1KMT2AALDH1A1 | |
| SCHEMBL25003794 | 0.85 | PLK1 (0.49) | MAPTNPC1MEN1KMT2AALDH1A1 | |
| SCHEMBL29961676 | 0.84 | NPC1 (0.56) | CA1CA2MAPTNPC1MEN1 | |
| SCHEMBL25002922 | 0.84 | KMT2A (0.56) | CA1CA2MAPTNPC1MEN1 | |
| SCHEMBL25003153 | 0.83 | KMT2A (0.48) | NPC1MEN1KMT2AKDM4ERAB9A | |
| SCHEMBL25003131 | 0.81 | MAP4K4 (0.55) | MAPTMEN1KMT2ACLK4ALDH1A1 | |
| SCHEMBL25003827 | 0.80 | FDPS (0.46) | MAPTNPC1MEN1KMT2AALDH1A1 | |
| SCHEMBL27237428 | 0.76 | KMT2A (0.58) | MAPTNPC1MEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023010192-A1 | N-ACYLHYDRAZONE COMPOUNDS CAPABLE OF INHIBITING NAV1.7 AND/OR NAV1.8, PROCESSES FOR THE PREPARATION THEREOF, COMPOSITIONS, USES, METHODS FOR TREATMENT USING SAME, AND KITS | EUROFARMA LABORATÓRIOS S.A. (BR) | 2023-02-09 | — | — | WO | disclosed |