Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FDPS | P14324 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | TYK2 | P29597 | 1/20 | 0.41 |
| ▸ | JAK3 | P52333 | 1/20 | 0.41 |
| ▸ | XDH | P47989 | 1/20 | 0.40 |
| ▸ | GRM5 | P41594 | 3/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | LNPEP | Q9UIQ6 | 1/20 | 0.38 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25002923 | 0.84 | FDPS (0.44) | FDPSLMNAALDH1A1NPC1RAB9A | |
| SCHEMBL25003161 | 0.83 | FDPS (0.58) | FDPSLMNAALDH1A1NPC1RAB9A | |
| SCHEMBL25003826 | 0.80 | CA1 (0.54) | LMNAALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL25003126 | 0.79 | ALDH1A1 (0.51) | LMNAALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL25003144 | 0.79 | KMO (0.51) | FDPSLMNAALDH1A1NPC1RAB9A | |
| SCHEMBL25003802 | 0.79 | FDPS (0.48) | FDPSLMNAALDH1A1NPC1RAB9A | |
| SCHEMBL25003134 | 0.77 | NPC1 (0.51) | LMNAALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL25003153 | 0.77 | KMT2A (0.48) | NPC1RAB9ASMN1; SMN2MEN1KMT2A | |
| SCHEMBL25003794 | 0.77 | PLK1 (0.49) | LMNAALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL27237488 | 0.76 | HDAC6 (0.47) | LMNAALDH1A1NPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023010192-A1 | N-ACYLHYDRAZONE COMPOUNDS CAPABLE OF INHIBITING NAV1.7 AND/OR NAV1.8, PROCESSES FOR THE PREPARATION THEREOF, COMPOSITIONS, USES, METHODS FOR TREATMENT USING SAME, AND KITS | EUROFARMA LABORATÓRIOS S.A. (BR) | 2023-02-09 | — | — | WO | disclosed |