SCHEMBL250103

SCHEMBL250103

CCOC(=O)C(F)C(C)=O

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 6/20 0.48
LMNA P02545 1/20 0.48
HSD17B10 Q99714 1/20 0.48
ALOX15 P16050 1/20 0.40
MGAM O43451 1/20 0.40
GAA P10253 1/20 0.40
SI P14410 1/20 0.40
MGAM2 Q2M2H8 1/20 0.40
SOAT1 P35610 1/20 0.40
TRPA1 O75762 1/20 0.37
GLO1 Q04760 1/20 0.37
CYP2D6 P10635 1/20 0.35
CYP2C9 P11712 1/20 0.35
CYP2C19 P33261 1/20 0.35
TSHR P16473 1/20 0.34
EGLN1 Q9GZT9 1/20 0.34
PIN1 Q13526 1/20 0.34
HPGD P15428 1/20 0.34
MEN1 O00255 1/20 0.33
NPC1 O15118 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL223479 0.87 ALDH1A1 (0.50) ALDH1A1LMNAHSD17B10ALOX15MGAM
SCHEMBL31473123 0.80 ALDH1A1 (0.32) ALDH1A1LMNAHSD17B10
SCHEMBL18666926 0.80 ALDH1A1 (0.43) ALDH1A1LMNAHSD17B10ALOX15MGAM
SCHEMBL30870369 0.80 ALDH1A1 (0.43) ALDH1A1LMNAHSD17B10ALOX15MGAM
SCHEMBL8923960 0.80 ALDH1A1 (0.43) ALDH1A1LMNAHSD17B10ALOX15MGAM
SCHEMBL3782518 0.78 SOAT1 (0.44) ALDH1A1LMNAHSD17B10ALOX15MGAM
SCHEMBL457732 0.78 ALDH1A1 (0.42) ALDH1A1LMNAHSD17B10ALOX15MGAM
SCHEMBL27599975 0.78 ALDH1A1 (0.41) ALDH1A1LMNAHSD17B10ALOX15MGAM
SCHEMBL7406646 0.76 ALDH1A1 (0.40) ALDH1A1LMNAHSD17B10ALOX15MGAM
Water SCHEMBL10546271 0.76 ALDH1A1 (0.40) ALDH1A1LMNAHSD17B10ALOX15MGAM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 380 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-120136761-A Method for synthesizing pyrrole compound 南京理工大学 2025-06-13 CN claimed
CN-119751361-A Synthesis method of compound 2, 4-dichloro-5-fluoro-6-methylpyrimidine 上海毕得医药科技股份有限公司 2025-04-04 CN claimed
CN-108218702-B Preparation method of 2-fluoro ethyl acetoacetate 湖北卓熙氟化股份有限公司 2020-10-09 CN claimed
CN-111484455-A Synthetic method of 2-chloro-5-fluoro-6-methylpyrimidine 南京普锐达医药科技有限公司 2020-08-04 CN claimed
JP-60058087-A None JP disclosed
US-20260132147-A1 BAX INHIBITORS AND USES THEREOF CASE WESTERN RESERVE UNIV (US) 2026-05-14 US disclosed
US-20260055116-A1 SUBSTITUTED TETRAHYDROPYRROLO-PYRIDINONE COMPOUNDS AND THEIR USE IN TREATING MEDICAL CONDITIONS KARUNA THERAPEUTICS INC (US) 2026-02-26 US disclosed
US-12558810-B2 Method for manufacturing ceramic article and ceramic article CANON KABUSHIKI KAISHA (JP) 2026-02-24 US disclosed
US-20260041671-A1 BRM TARGETING COMPOUNDS AND ASSOCIATED METHODS OF USE ARVINAS OPERATIONS INC (US) 2026-02-12 US disclosed
US-12539292-B2 BRM targeting compounds and associated methods of use ARVINAS OPERATIONS, INC. (US) 2026-02-03 US disclosed
US-12479857-B2 Bax inhibitors and uses thereof CASE WESTERN RESERVE UNIVERSITY (US) 2025-11-25 US disclosed
US-20250340548-A1 KRAS G12C INHIBITORS FRONTIER MEDICINES CORP (US) 2025-11-06 US disclosed
WO-1995014646-A1 THE PREPARATION OF DICARBONYLS BNFL FLUOROCHEMICALS LTD (GB) 1995-06-01 WO disclosed
WO-1995010519-A1 QUINOLIZINONE TYPE COMPOUNDS ABBOTT LABORATORIES (US) 1995-04-20 WO disclosed
US-5391811-A Process for the preparation of α-fluoro-β-dicarbonyl compounds BAYER AKTIENGESELLSCHAFT (DE) 1995-02-21 US disclosed
EP-0527889-A4 QUINOLIZINONE TYPE COMPOUNDS ABBOTT LAB (US) 1994-08-10 EP disclosed
EP-0527889-A1 QUINOLIZINONE TYPE COMPOUNDS ABBOTT LABORATORIES (US) 1993-02-24 EP disclosed
WO-1991016894-A1 QUINOLIZINONE TYPE COMPOUNDS ABBOTT LABORATORIES (US) 1991-11-14 WO disclosed
JP-S6058087-A PRODUCTION OF ALPHA-FLUORO-BETA-HYDROXYCARBOXYLIC ACID ESTER DAIKIN IND LTD 1985-04-04 JP disclosed
JP-S0658087-A 0001-01-01 JP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260132147-A1 BAX INHIBITORS AND USES THEREOF BAX, BCL2, BAK1 ALDH1A1 4585/4885LMNA 76/4885HSD17B10 3457/4885
US-12539292-B2 BRM targeting compounds and associated methods of use ADRM1, SUMO2, BAZ1A ALDH1A1 3935/4885LMNA 988/4885HSD17B10 2923/4885
US-12558810-B2 Method for manufacturing ceramic article and ceramic article CCT2, TMT1A, U2AF2 ALDH1A1 4075/4885LMNA 1416/4885HSD17B10 3564/4885
US-20250340548-A1 KRAS G12C INHIBITORS KRAS, NRAS, HRAS ALDH1A1 3319/4885LMNA 2522/4885HSD17B10 4044/4885
US-20260041671-A1 BRM TARGETING COMPOUNDS AND ASSOCIATED METHODS OF USE ADRM1, VHL, BAZ1A ALDH1A1 3742/4885LMNA 809/4885HSD17B10 3487/4885
US-12479857-B2 Bax inhibitors and uses thereof BAX, TMBIM6, BCL2 ALDH1A1 4296/4885LMNA 537/4885HSD17B10 2484/4885
US-20260055116-A1 SUBSTITUTED TETRAHYDROPYRROLO-PYRIDINONE COMPOUNDS AND THEIR USE IN TREATING MEDICAL CONDITIONS CHRM3, CHRM2, CHRM1 ALDH1A1 704/4885LMNA 4175/4885HSD17B10 756/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.