SCHEMBL250237

SCHEMBL250237

C[SiH2]O[Si](C)(C)c1ccccc1

nearest known ligand 0.37

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
ESR1 P03372 1/20 0.37
ESR2 Q92731 1/20 0.37
NR1H2 P55055 1/20 0.31
NR1H3 Q13133 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28789682 0.83 ESR1 (0.32) ESR1ESR2
SCHEMBL28969403 0.81 ESR1 (0.31) ESR1ESR2
SCHEMBL182248 0.81 ESR1 (0.37) ESR1ESR2NR1H2NR1H3
SCHEMBL4435870 0.79 ESR1 (0.40) ESR1ESR2NR1H2NR1H3
SCHEMBL10784166 0.78 ESR1 (0.33) ESR1ESR2
SCHEMBL3309054 0.78 ESR1 (0.33) ESR1ESR2
SCHEMBL10695074 0.78 ESR1 (0.33) ESR1ESR2
SCHEMBL4434894 0.77 ESR1 (0.34) ESR1ESR2
SCHEMBL890423 0.77 ESR1 (0.34) ESR1ESR2
SCHEMBL4445118 0.76 ESR1 (0.33) ESR1ESR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 681 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4626665-A1 SILICONE MANUFACTURING Dow Silicones Corporation (US) 2025-10-08 EP claimed
WO-2024118393-A1 SILICONE MANUFACTURING DOW SILICONES CORPORATION (US) 2024-06-06 WO claimed
WO-2024084490-A1 EMERGENCY RESCUE & AID SUPPORT SYSTEM - ERASS RAM KISHORE THANDAL MURALIRAJA (IN) 2024-04-25 WO claimed
CN-110964166-A Preparation method of polyurethane elastomer 青岛科技大学 2020-04-07 CN claimed
EP-1800660-B2 Cosmetic ingredient comprising at least one cationic poly(vinyllactam), at least one specific cross-linked cationic polymer and at least one non-volatile silicon OREAL (FR) 2019-03-27 EP claimed
EP-1800660-B1 Cosmetic ingredient comprising at least one cationic poly(vinyllactam), at least one specific cross-linked cationic polymer and at least one non-volatile silicon ORÉAL L (FR) 2016-02-17 EP claimed
EP-1379215-B1 COSMETIC COMPOSITIONS CONTAINING A STARCH PHOSPHATE AND A CATIONIC POLYMER AND USES THEREOF ORÉAL L (FR) 2015-09-16 EP claimed
US-8900561-B2 Hair treatment agents containing 4-morpholino-methyl-substituted silicone(s) and conditioning agent(s) HENKEL AG & CO. KGAA (DE) 2014-12-02 US claimed
US-20140271750-A1 HAIR TREATMENT AGENTS CONTAINING 4-MORPHOLINO-METHYL-SUBSTITUTED SILICONE(S) AND CONDITIONING AGENT(S) HENKEL AG & CO. KGAA (DE) 2014-09-18 US claimed
EP-2338467-A1 Cosmetic composition including at least one volatile linear alkane, at least one silicone and at least one glyceride with a specific ratio of glyceride to silicone L'Oréal (FR) 2011-06-29 EP claimed
US-5308551-A Detergents with silicones, myristates and alkanolamides L'OREAL (FR) 1994-05-03 US claimed
EP-0587637-A1 SILICON AND LATEX-BASED COMPOSITION FOR THE TREATMENT OF KERATINOUS SUBSTANCES. OREAL (FR) 1994-03-23 EP claimed
WO-1994005749-A1 HIGH STRENGTH, LOW CONDUCTIVITY ELECTRORHEOLOGICAL MATERIALS LORD CORPORATION (US) 1994-03-17 WO claimed
US-5275755-A Surfactant blend for shampoo L'OREAL (FR) 1994-01-04 US claimed
EP-0457688-B1 Washing compositions based on silicone and fatty alcohols containing ethers and/or thioethers or sulfoxyde OREAL (FR) 1993-10-27 EP claimed
EP-0521748-A1 Washing and/or conditioning composition for keratinous material containing a silicone and an amphoteric polymer derivative of diallyldialkylammonium and an anionic monomer L'OREAL (FR) 1993-01-07 EP claimed
WO-1992021316-A1 SILICON AND LATEX-BASED COMPOSITION FOR THE TREATMENT OF KERATINOUS SUBSTANCES L'OREAL (FR) 1992-12-10 WO claimed
EP-0473508-A1 Cleansing composition containing silicones and method of use L'OREAL (FR) 1992-03-04 EP claimed
US-5085913-A Cured dielectric material of polysiloxane, silica filler, tin catalyst and copper (II) benzoylacetonate AT&T BELL LABORATORIES (US) 1992-02-04 US claimed
EP-0457688-A1 Washing compositions based on silicone and fatty alcohols containing ethers and/or thioethers or sulfoxyde L'OREAL (FR) 1991-11-21 EP claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140271750-A1 HAIR TREATMENT AGENTS CONTAINING 4-MORPHOLINO-METHYL-SUBSTITUTED SILICONE(S) AND CONDITIONING AGENT(S) BHMT2, MGMT, SMC3 ESR1 3194/4885ESR2 3145/4885NR1H2 2185/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.