SCHEMBL25035756

SCHEMBL25035756

CC(C)Cn1cc(-c2ccc(F)cc2)c(=O)c(C(=O)O)n1

nearest known ligand 0.40

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
ACHE P22303 2/20 0.39
S1PR1 P21453 1/20 0.39
ALDH1A1 P00352 3/20 0.37
HPGD P15428 2/20 0.37
KDM4E B2RXH2 2/20 0.37
HSD17B10 Q99714 2/20 0.37
APOBEC3G Q9HC16 2/20 0.37
TSHR P16473 1/20 0.37
CACNA1B Q00975 2/20 0.36
KMT2A Q03164 1/20 0.36
TRPA1 O75762 1/20 0.36
RXFP1 Q9HBX9 1/20 0.35
PTGS2 P35354 1/20 0.35
GRIN2B Q13224 1/20 0.34
PTGDR2 Q9Y5Y4 1/20 0.34
KDM4C Q9H3R0 1/20 0.34
TGFBR1 P36897 1/20 0.34
TGFBR2 P37173 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29154957 0.85 LMNA (0.46) ALDH1A1HPGDKDM4EHSD17B10KMT2A
SCHEMBL21753512 0.81 KMT2A (0.39) ACHEALDH1A1HPGDKDM4EHSD17B10
SCHEMBL25035766 0.81 ALDH1A1 (0.40) ALDH1A1HPGDKDM4EHSD17B10KMT2A
SCHEMBL23159770 0.80 ALDH1A1 (0.39) ALDH1A1HPGDKDM4EKMT2APTGS2
SCHEMBL28556772 0.79 DGAT1 (0.38) ALDH1A1HPGDKDM4EHSD17B10KMT2A
SCHEMBL23160878 0.79 CSNK1D (0.48) KMT2A
SCHEMBL25037802 0.75 AXL (0.43)
SCHEMBL22188196 0.74 TRPA1 (0.39) ALDH1A1HPGDKDM4EHSD17B10APOBEC3G
SCHEMBL25035781 0.73 SCD (0.40)
SCHEMBL21753543 0.72 CSNK1D (0.44) ALDH1A1HPGDKMT2APTGS2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117561260-A Heterocyclic compound, preparation method and application thereof 四川科伦博泰生物医药股份有限公司 2024-02-13 CN disclosed
WO-2023016296-A1 HETEROCYCLIC COMPOUND AND PREPARATION METHOD THEREFOR AND USE THEREOF 四川科伦博泰生物医药股份有限公司 2023-02-16 WO disclosed