Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.33 |
| ▸ | RORC | P51449 | 1/20 | 0.33 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.32 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.32 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.32 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.31 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.31 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9683779 | 0.86 | TSHR (0.56) | TSHRHPGDUSP2ALDH1A1GAA | |
| SCHEMBL6681936 | 0.80 | TSHR (0.50) | TSHRHPGDPKMMAOAMAOB | |
| SCHEMBL300990 | 0.80 | TSHR (0.50) | TSHRHPGDUSP2ALDH1A1GAA | |
| SCHEMBL11421517 | 0.79 | GABRA1 (0.44) | TSHRHPGDALDH1A1MAOAMAOB | |
| SCHEMBL29573338 | 0.79 | TSHR (0.59) | TSHRALDH1A1ALOX15MAOAMAOB | |
| SCHEMBL3708329 | 0.79 | TSHR (0.59) | TSHRALDH1A1ALOX15MAOAMAOB | |
| SCHEMBL13981277 | 0.78 | TSHR (0.48) | TSHRHPGDALDH1A1PKMMAOA | |
| SCHEMBL10798080 | 0.78 | TSHR (0.48) | TSHRHPGDUSP2ALDH1A1GAA | |
| SCHEMBL398716 | 0.77 | TSHR (0.47) | TSHRHPGDUSP2ALDH1A1GAA | |
| SCHEMBL21451620 | 0.77 | TSHR (0.47) | TSHRHPGDHTTGRM2RORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130217783-A1 | Therapeutic Compounds | SIGNATURE THERAPEUTICS, INC. (US) | 2013-08-22 | — | — | US | disclosed |
| US-20130217783-A1 | Therapeutic Compounds | SIGNATURE THERAPEUTICS, INC. (US) | 2013-08-22 | — | — | US | disclosed |
| US-20130217783-A1 | Therapeutic Compounds | SIGNATURE THERAPEUTICS, INC. (US) | 2013-08-22 | — | — | US | disclosed |
| US-8350097-B2 | Therapeutic compounds | SIGNATURE THERAPEUTICS, INC. (US) | 2013-01-08 | — | — | US | disclosed |
| US-8350097-B2 | Therapeutic compounds | SIGNATURE THERAPEUTICS, INC. (US) | 2013-01-08 | — | — | US | disclosed |
| US-8350097-B2 | Therapeutic compounds | SIGNATURE THERAPEUTICS, INC. (US) | 2013-01-08 | — | — | US | disclosed |
| US-20120196939-A1 | Therapeutic Compounds | SOWOOD HEALTHCARE LLC | 2012-08-02 | — | — | US | disclosed |
| US-20120196939-A1 | Therapeutic Compounds | SOWOOD HEALTHCARE LLC | 2012-08-02 | — | — | US | disclosed |
| US-20120196939-A1 | Therapeutic Compounds | SOWOOD HEALTHCARE LLC | 2012-08-02 | — | — | US | disclosed |
| US-8173849-B2 | Therapeutic compounds | SIGNATURE THERAPEUTICS, INC. (US) | 2012-05-08 | — | — | US | disclosed |
| US-8173849-B2 | Therapeutic compounds | SIGNATURE THERAPEUTICS, INC. (US) | 2012-05-08 | — | — | US | disclosed |
| EP-2152651-B1 | THERAPEUTIC COMPOUNDS | PHARMACOFORE INC (US) | 2012-01-04 | — | — | EP | disclosed |
| EP-2392559-A1 | Therapeutic compounds | Pharmacofore, Inc. (US) | 2011-12-07 | — | — | EP | disclosed |
| EP-2392559-A1 | Therapeutic compounds | Pharmacofore, Inc. (US) | 2011-12-07 | — | — | EP | disclosed |
| US-20100249246-A1 | Therapeutic Compounds | PHARMACOFORE, INC. (US) | 2010-09-30 | — | — | US | disclosed |
| US-20100249246-A1 | Therapeutic Compounds | PHARMACOFORE, INC. (US) | 2010-09-30 | — | — | US | disclosed |
| US-20100249246-A1 | Therapeutic Compounds | PHARMACOFORE, INC. (US) | 2010-09-30 | — | — | US | disclosed |
| CN-101687746-A | therapeutic compounds | PHARMACOFORE INC | 2010-03-31 | — | — | CN | disclosed |
| EP-2152651-A1 | THERAPEUTIC COMPOUNDS | Pharmacofore, Inc. (US) | 2010-02-17 | — | — | EP | disclosed |
| WO-2008141099-A1 | THERAPEUTIC COMPOUNDS | PHARMACOFORE, INC. (US) | 2008-11-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130217783-A1 | Therapeutic Compounds | OPRM1, OGFR, UGT1A1 | TSHR 1530/4885HPGD 365/4885USP2 4673/4885 |
| US-20100249246-A1 | Therapeutic Compounds | OPRM1, OGFR, UGT1A1 | TSHR 1530/4885HPGD 365/4885USP2 4673/4885 |
| US-20120196939-A1 | Therapeutic Compounds | OPRM1, OPRD1, SCN1B | TSHR 1877/4885HPGD 566/4885USP2 4750/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.