Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 1/20 | 0.44 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.42 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.42 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.42 |
| ▸ | MAP2K4 | P45985 | 2/20 | 0.41 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 2/20 | 0.40 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.40 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22608971 | 0.78 | OPRM1 (0.49) | OPRM1MAP2K4MAP2K7BRD4 | |
| SCHEMBL26154173 | 0.78 | OPRM1 (0.47) | OPRM1MAP2K4MAP2K7BRD4BRPF1 | |
| SCHEMBL24369093 | 0.76 | CHRNB2 (0.38) | OPRM1CHRNB2CHRNA4MAP2K4MAP2K7 | |
| SCHEMBL2916758 | 0.74 | KCNA5 (0.49) | CHRNB2CHRNA7CHRNA4L3MBTL1POLB | |
| SCHEMBL24233882 | 0.73 | MEN1 (0.50) | CHRNB2CHRNA7CHRNA4L3MBTL1MEN1 | |
| SCHEMBL25099264 | 0.72 | SCN9A (0.46) | CHRNB2CHRNA7CHRNA4 | |
| SCHEMBL24369696 | 0.72 | SCN9A (0.46) | CHRNB2CHRNA7CHRNA4 | |
| SCHEMBL2911688 | 0.71 | CA2 (0.47) | CHRNB2CHRNA7CHRNA4L3MBTL1MEN1 | |
| SCHEMBL17538757 | 0.71 | CHRNB2 (0.46) | CHRNB2CHRNA7CHRNA4L3MBTL1MEN1 | |
| SCHEMBL3088257 | 0.71 | HTR6 (0.56) | OPRM1MAP2K4MAP2K7BRPF1AAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230077316-A1 | CTPS1 INHIBITORS AND USES THEREOF | NIMBUS DISCOVERY, INC. | 2023-03-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230077316-A1 | CTPS1 INHIBITORS AND USES THEREOF | CTPS1, CTPS2, ECHS1 | OPRM1 4784/4885CHRNB2 4726/4885CHRNA7 4678/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.