Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Propylene Glycol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 4/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | SCN4A | P35499 | 3/20 | 0.30 |
| ▸ | USP2 | O75604 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.30 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.30 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.30 |
| ▸ | KCNK2 | O95069 | 1/20 | 0.30 |
| ▸ | GBA1 | P04062 | 1/20 | 0.30 |
| ▸ | MAOA | P21397 | 1/20 | 0.30 |
| ▸ | HTR2A | P28223 | 1/20 | 0.30 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Propylene Glycol SCHEMBL27811556 | 1.00 | TDP1 (0.53) | TDP1HSD17B10TSHRMAPK1ALDH1A1 | |
| Propylene Glycol SCHEMBL6567284 | 1.00 | TDP1 (0.53) | TDP1HSD17B10TSHRMAPK1ALDH1A1 | |
| SCHEMBL7011240 | 0.86 | — | — | |
| Ethylene Glycol SCHEMBL450520 | 0.83 | ALDH1A1 (0.35) | TSHRMAPK1ALDH1A1SCN4ALMNA | |
| Ethylene Glycol SCHEMBL2723632 | 0.83 | ALDH1A1 (0.35) | TSHRMAPK1ALDH1A1SCN4ALMNA | |
| SCHEMBL114351 | 0.83 | — | — | |
| SCHEMBL30985226 | 0.83 | — | — | |
| SCHEMBL19654931 | 0.78 | TP53 (0.35) | TDP1TSHR | |
| Propylene Glycol SCHEMBL535998 | 0.78 | TDP1 (0.59) | TDP1HSD17B10TSHRMAPK1ALDH1A1 | |
| Di(Hydroxyethyl)Ether SCHEMBL14054643 | 0.77 | TSHR (0.50) | HSD17B10TSHRMAPK1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 751 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260098123-A1 | LIGNIN-DERIVED CURING AGENTS, AS WELL AS THEIR USE IN RESIN COMPOSITIONS AND METHOD FOR PREPARING SAID LIGNIN-DERIVED CURING AGENTS | VITO NV (BE) | 2026-04-09 | — | — | US | claimed |
| US-12469851-B2 | Anode protective layer for lithium-sulfur cells | Lyten, Inc. (US) | 2025-11-11 | — | — | US | claimed |
| EP-3774992-B9 | POLYMERIC MATERIALS AND ARTICLES MANUFACTURED THERE FROM | PROCTER & GAMBLE (US) | 2025-10-22 | — | — | EP | claimed |
| EP-3774992-B1 | POLYMERIC MATERIALS AND ARTICLES MANUFACTURED THERE FROM | PROCTER & GAMBLE (US) | 2025-09-03 | — | — | EP | claimed |
| US-12338322-B2 | Photo-responsive dampening and toughening agents | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE ARMY (US) | 2025-06-24 | — | — | US | claimed |
| WO-2024263666-A1 | CURABLE COMPOSITIONS WITH LOW EXOTHERM | HENKEL AG & CO. KGAA (DE) | 2024-12-26 | — | — | WO | claimed |
| US-11958253-B2 | Use of isosorbide | ELANTAS EUROPE S.R.L. (IT) | 2024-04-16 | — | — | US | claimed |
| US-11951449-B2 | Method for preparing organic-inorganic hybrid microcapsule | LG HOUSEHOLD & HEALTH CARE LTD. (KR) | 2024-04-09 | — | — | US | claimed |
| US-11955603-B2 | Composite electrolytes | QUANTUMSCAPE BATTERY, INC. (US) | 2024-04-09 | — | — | US | claimed |
| WO-2024068653-A1 | LIGNIN-DERIVED CURING AGENTS, AS WELL AS THEIR USE IN RESIN COMPOSITIONS AND METHOD FOR PREPARING SAID LIGNIN-DERIVED CURING AGENTS | VITO NV (BE) | 2024-04-04 | — | — | WO | claimed |
| WO-2006127570-A2 | POLYPROPYLENE SILICATE NANOCOMPOSITES | CORNELL RESEARCH FOUNDATION, INC. (US) | 2006-11-30 | — | — | WO | claimed |
| US-20060260677-A1 | Polypropylene silicate nanocomposites | CORNELL RESEARCH FOUNDATION, INC. (US) | 2006-11-23 | — | — | US | claimed |
| WO-2006063442-A1 | SILICA-FILLED ELASTOMERIC COMPOUNDS | LANXESS INC. (CA) | 2006-06-22 | — | — | WO | claimed |
| WO-2005111116-A1 | BIOLOGICAL MOLECULE-REACTIVE HYDROPHILIC SILICONE SURFACE | MCMASTER UNIVERSITY (CA) | 2005-11-24 | — | — | WO | claimed |
| EP-1542926-A1 | METHODS AND COMPOUNDS FOR CONTROLLING THE MORPHOLOGY AND SHRINKAGE OF SILICA DERIVED FROM POLYOL-MODIFIED SILANES | McMaster University (CA) | 2005-06-22 | — | — | EP | claimed |
| US-20040249082-A1 | Protein compatible methods and compounds for controlling the morphology and shrinkage of silica derived from polyol-modified silanes | MCMASTER UNIVERSITY (CA) | 2004-12-09 | — | — | US | claimed |
| US-20040211730-A1 | Methods and compounds for controlling the morphology and shrinkage of silica derived from polyol-modified silanes | ZHANG ZHENG | 2004-10-28 | — | — | US | claimed |
| US-6784274-B2 | FOR REDUCING THE ELECTRODE IMPEDANCE OF IMPLANTABLE BIOSENSORS; COATING OF A HYDROGEL FORMED FROM A DIISOCYANATE, A HYDROPHILIC POLYMER SELECTED FROM A POLYOXYETHYLENE GLYCOL AND JEFFAMINES?, AND A CHAIN EXTENDER | MINIMED INC. | 2004-08-31 | — | — | US | claimed |
| WO-2004018360-A1 | METHODS AND COMPOUNDS FOR CONTROLLING THE MORPHOLOGY AND SHRINKAGE OF SILICA DERIVED FROM POLYOL-MODIFIED SILANES | MCMASTER UNIVERSITY (CA) | 2004-03-04 | — | — | WO | claimed |
| US-6462162-B2 | REDUCING ELECTRODE IMPEDANCE OF IMPLANTABLE BIOSENSORS BY COATING THE SURFACE WITH UNIFORM HYDROGEL (POLYUREA, POLYURETHANE) WHICH ALLOWS UNIMPEDED WATER MOVEMENT | MINIMED INC. | 2002-10-08 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20260098123-A1 | LIGNIN-DERIVED CURING AGENTS, AS WELL AS THEIR USE IN RESIN COMPOSITIONS AND METHOD FOR PREPARING SAID LIGNIN-DERIVED CURING AGENTS | EHMT1, SRM, EHMT2 | TDP1 1797/4885HSD17B10 4664/4885TSHR 4693/4885 |
| US-11951449-B2 | Method for preparing organic-inorganic hybrid microcapsule | INCENP, PHOSPHO1, CHMP4B | TDP1 3015/4885HSD17B10 4478/4885TSHR 4626/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.