Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | BACE1 | P56817 | 2/20 | 0.42 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.42 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.42 |
| ▸ | TACR1 | P25103 | 1/20 | 0.42 |
| ▸ | LTA4H | P09960 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | CDK1 | P06493 | 1/20 | 0.41 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | RORC | P51449 | 1/20 | 0.39 |
| ▸ | RHOC | P08134 | 2/20 | 0.39 |
| ▸ | RHOA | P61586 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1578847 | 0.86 | HPGD (0.46) | NLRP3LTA4HEPHX2LMNACNR2 | |
| SCHEMBL1578838 | 0.85 | EPHX2 (0.47) | NLRP3LTA4HEPHX2RORCCNR1 | |
| SCHEMBL1578491 | 0.84 | LMNA (0.40) | GLACDK1MRGPRX4LMNARHOC | |
| SCHEMBL1578717 | 0.84 | BACE1 (0.41) | GLABACE1BACE2NLRP3TACR1 | |
| SCHEMBL1579320 | 0.82 | POLB (0.57) | TACR1EPHX2LMNACNR1 | |
| SCHEMBL4655121 | 0.79 | LTA4H (0.59) | BACE1BACE2NLRP3TACR1LTA4H | |
| SCHEMBL30795667 | 0.77 | GPR52 (0.55) | EPHX2MRGPRX4RHOCRHOA | |
| SCHEMBL1578844 | 0.77 | GPR52 (0.55) | EPHX2MRGPRX4RHOCRHOA | |
| SCHEMBL1578975 | 0.75 | MRGPRX4 (0.57) | EPHX2MRGPRX4RHOCRHOA | |
| SCHEMBL30794508 | 0.75 | MRGPRX4 (0.57) | EPHX2MRGPRX4RHOCRHOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2310357-B1 | POTASSIUM ION CHANNEL MODULATORS & USES THEREOF | RAMOT AT TEL AVIV UNIV LIMITED (IL) | 2019-09-11 | — | — | EP | claimed |
| US-20160374969-A1 | POTASSIUM ION CHANNEL MODULATORS & USES THEREOF | RAMOT AT TEL-AVIV UNIVERSITY LTD. (IL) | 2016-12-29 | — | — | US | claimed |
| US-20110245250-A1 | POTASSIUM ION CHANNEL MODULATORS & USES THEREOF | RAMOT AT TEL-AVIV UNIVERSITY LTD. (IL) | 2011-10-06 | — | — | US | claimed |
| CN-102159535-A | Potassium ion channel modulators and uses thereof | UNIV RAMOT | 2011-08-17 | — | — | CN | claimed |
| EP-4584250-A1 | COMBINATION THERAPIES INCLUDING METAL CHANNEL ACTIVATORS | Biohaven Therapeutics Ltd. (VG) | 2025-07-16 | — | — | EP | disclosed |
| EP-4580679-A1 | COMBINATION THERAPIES INCLUDING METAL CHANNEL ACTIVATORS AND NMDA RECEPTOR ANTAGONISTS | Biohaven Therapeutics Ltd. (VG) | 2025-07-09 | — | — | EP | disclosed |
| WO-2024054807-A1 | COMBINATION THERAPIES INCLUDING METAL CHANNEL ACTIVATORS AND TDP-43 MODULATORS | BIOHAVEN THERAPEUTICS LTD. (VG) | 2024-03-14 | — | — | WO | disclosed |
| WO-2024054811-A1 | COMBINATION THERAPIES INCLUDING METAL CHANNEL ACTIVATORS | BIOHAVEN THERAPEUTICS LTD. (VG) | 2024-03-14 | — | — | WO | disclosed |
| WO-2024050389-A1 | COMBINATION THERAPIES INCLUDING METAL CHANNEL ACTIVATORS AND NMDA RECEPTOR ANTAGONISTS | BIOHAVEN THERAPEUTICS LTD. (VG) | 2024-03-07 | — | — | WO | disclosed |
| US-20200308102-A1 | MODULATORS OF POTASSIUM ION AND TRPV1 CHANNELS AND USES THEREOF | RAMOT AT TEL-AVIV UNIVERSITY LTD. (IL) | 2020-10-01 | — | — | US | disclosed |
| EP-2310357-B1 | POTASSIUM ION CHANNEL MODULATORS & USES THEREOF | RAMOT AT TEL AVIV UNIV LIMITED (IL) | 2019-09-11 | — | — | EP | disclosed |
| EP-2310357-B1 | POTASSIUM ION CHANNEL MODULATORS & USES THEREOF | RAMOT AT TEL AVIV UNIV LIMITED (IL) | 2019-09-11 | — | — | EP | disclosed |
| US-20160374969-A1 | POTASSIUM ION CHANNEL MODULATORS & USES THEREOF | RAMOT AT TEL-AVIV UNIVERSITY LTD. (IL) | 2016-12-29 | — | — | US | disclosed |
| US-9464052-B2 | Potassium ion channel modulators and uses thereof | RAMOT AT TEL-AVIV UNIVERSITY LTD. (IL) | 2016-10-11 | — | — | US | disclosed |
| US-9464052-B2 | Potassium ion channel modulators and uses thereof | RAMOT AT TEL-AVIV UNIVERSITY LTD. (IL) | 2016-10-11 | — | — | US | disclosed |
| US-9464052-B2 | Potassium ion channel modulators and uses thereof | RAMOT AT TEL-AVIV UNIVERSITY LTD. (IL) | 2016-10-11 | — | — | US | disclosed |
| US-20110245250-A1 | POTASSIUM ION CHANNEL MODULATORS & USES THEREOF | RAMOT AT TEL-AVIV UNIVERSITY LTD. (IL) | 2011-10-06 | — | — | US | disclosed |
| US-20110245250-A1 | POTASSIUM ION CHANNEL MODULATORS & USES THEREOF | RAMOT AT TEL-AVIV UNIVERSITY LTD. (IL) | 2011-10-06 | — | — | US | disclosed |
| US-20110245250-A1 | POTASSIUM ION CHANNEL MODULATORS & USES THEREOF | RAMOT AT TEL-AVIV UNIVERSITY LTD. (IL) | 2011-10-06 | — | — | US | disclosed |
| CN-102159535-A | Potassium ion channel modulators and uses thereof | UNIV RAMOT | 2011-08-17 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110245250-A1 | POTASSIUM ION CHANNEL MODULATORS & USES THEREOF | SCN1B, KCNN3, SCN2B | GLA 4573/4885BACE1 3653/4885BACE2 3870/4885 |
| US-20160374969-A1 | POTASSIUM ION CHANNEL MODULATORS & USES THEREOF | KCNJ11, KCNJ1, KCNJ2 | GLA 2443/4885BACE1 3623/4885BACE2 3437/4885 |
| US-20200308102-A1 | MODULATORS OF POTASSIUM ION AND TRPV1 CHANNELS AND USES THEREOF | TRPV1, TRPV2, TRPV5 | GLA 2681/4885BACE1 2808/4885BACE2 2226/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.