Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1B | P49286 | 4/20 | 0.52 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.52 |
| ▸ | PLA2G2A | P14555 | 9/20 | 0.51 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.49 |
| ▸ | CCR2 | P41597 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25136 | 0.92 | MTNR1B (0.60) | MTNR1BMTNR1APLA2G2APLA2G1BCCR2 | |
| SCHEMBL6597958 | 0.86 | MAPT (0.57) | PLA2G2APLA2G1BCCR2MAPTTHRB | |
| SCHEMBL2157383 | 0.84 | MTNR1B (0.57) | MTNR1BMTNR1APLA2G2APLA2G1BCCR2 | |
| SCHEMBL5697008 | 0.80 | MTNR1A (0.52) | MTNR1BMTNR1APLA2G2APLA2G1BCCR2 | |
| SCHEMBL27555858 | 0.80 | PLA2G2A (0.50) | MTNR1BMTNR1APLA2G2APLA2G1BCCR2 | |
| SCHEMBL13632216 | 0.80 | MTNR1A (0.54) | MTNR1BMTNR1APLA2G2APLA2G1BMAPT | |
| SCHEMBL4789355 | 0.80 | PLA2G1B (0.46) | MTNR1BMTNR1APLA2G2APLA2G1BALDH1A1 | |
| SCHEMBL5765093 | 0.79 | PTGDR2 (0.42) | MTNR1BMTNR1APLA2G2APLA2G1BMAPT | |
| SCHEMBL8502436 | 0.79 | MTNR1A (0.46) | MTNR1BMTNR1APLA2G2APLA2G1BCCR2 | |
| SCHEMBL26613 | 0.78 | PLA2G2A (0.59) | MTNR1BMTNR1APLA2G2APLA2G1BCCR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1950200-A1 | [[3-(2-amino-1,2-dioxoethyl)-2-ethyl-1-(phenylmethyl)-11H-indol-4-yl]oxy]acetic acid methyl ester as sPLA2 inhibitor | ELI LILLY AND COMPANY (US) | 2008-07-30 | — | — | EP | disclosed |
| US-6433001-B1 | SEPTIC SHOCK, ALLERGIC RHINITIS, RHEUMATIC ARTHRITIS, ADULT RESPIRATORY DISTRESS SYNDROME, BRONCHIAL ASTHMA, TRAUMA, AND PANCREATITIS TREATMENT | ELI LILLY AND COMPANY | 2002-08-13 | — | — | US | disclosed |
| EP-0675110-B1 | 1H-Indole-3-glyoxylamide sPLA2 inhibitors | LILLY CO ELI (US) | 2002-07-10 | — | — | EP | disclosed |
| EP-1197484-A2 | 1H-Indole-3-glyoxylamide sPLA2 inhibitors | ELI LILLY AND COMPANY (US) | 2002-04-17 | — | — | EP | disclosed |
| EP-1081135-A2 | 1H-indole-3-glyoxylamide spla2 inhibitors | ELI LILLY AND COMPANY (US) | 2001-03-07 | — | — | EP | disclosed |
| US-6175021-B1 | HUMAN NON-PANCREATIC SECRETORY PHOSPHOLIPASE A2 (SPLA2); INHIBITS RELEASE OF ARACHIDONIC ACID TO TREAT SEPTIC SHOCK; ((3-(2-AMINO-1,2-DIOXOETHYL)-2-METHYL-1-(PHENYLMETHYL)-1H-INDOL-4 -YL)OXYLACETIC ACID, FOR EXAMPLE | ELI LILLY AND COMPANY | 2001-01-16 | — | — | US | disclosed |
| US-5919943-A | INHIBITION OF SPLA2 | ELI LILLY AND COMPANY (US) | 1999-07-06 | — | — | US | disclosed |
| US-5919810-A | SEPTIC SHOCK | ELI LILLY AND COMPANY (US) | 1999-07-06 | — | — | US | disclosed |
| US-5733923-A | SECRETORY PANCREATIC PHOSPHOLIPASE A2 | ELI LILLY AND COMPANY (US) | 1998-03-31 | — | — | US | disclosed |
| US-5654326-A | SEPTIC SHOCK; HUMAN NONPANCREATIC SECRETORY PHOSPHOLIPASE | ELI LILLY AND COMPANY (US) | 1997-08-05 | — | — | US | disclosed |
| EP-0675110-A1 | 1H-Indole-3-glyoxylamide sPLA2 inhibitors | ELI LILLY AND COMPANY (US) | 1995-10-04 | — | — | EP | disclosed |