Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 11/20 | 0.82 |
| ▸ | HTR2B | P41595 | 2/20 | 0.63 |
| ▸ | HTR7 | P34969 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | TTR | P02766 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28406723 | 0.91 | ALOX5 (0.67) | ALOX5HTR2BHTR7ALDH1A1MAPK1 | |
| SCHEMBL2483714 | 0.90 | ALOX5 (1.00) | ALOX5HTR2BHTR7ALDH1A1MAPK1 | |
| SCHEMBL30812968 | 0.90 | ALOX5 (1.00) | ALOX5HTR2BHTR7ALDH1A1MAPK1 | |
| SCHEMBL28403621 | 0.88 | ALOX5 (0.79) | ALOX5HTR2BHTR7ALDH1A1MAPK1 | |
| Phenoxazine SCHEMBL6270610 | 0.82 | ALOX5 (0.77) | ALOX5HTR2BHTR7TDP1MAPT | |
| SCHEMBL26115655 | 0.81 | ALOX5 (0.84) | ALOX5HTR2BHTR7MEN1KMT2A | |
| SCHEMBL7206703 | 0.81 | ALOX5 (0.55) | ALOX5HTR2BHTR7ALDH1A1MAPK1 | |
| SCHEMBL28400911 | 0.80 | ALOX5 (0.83) | ALOX5HTR2BHTR7ALDH1A1MAPK1 | |
| Bicarbonate SCHEMBL6271245 | 0.79 | ALOX5 (0.56) | ALOX5HTR2BHTR7TDP1MAPT | |
| SCHEMBL5115778 | 0.79 | HTR2B (0.62) | ALOX5HTR2BHTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107106566-A | Phacosclerosis inhibitor | 学校法人庆应义塾 | 2017-08-29 | — | — | CN | claimed |
| CN-107106566-A | Phacosclerosis inhibitor | 学校法人庆应义塾 | 2017-08-29 | — | — | CN | disclosed |
| US-8076348-B2 | Acylguanidine derivative or salt thereof | ASTELLAS PHARMA INC. (JP) | 2011-12-13 | — | — | US | disclosed |
| EP-1923387-B1 | ACYLGUANIDINE DERIVATIVE OR SALT THEREOF | ASTELLAS PHARMA INC (JP) | 2011-10-19 | — | — | EP | disclosed |
| US-20100168096-A1 | ACYLGUANIDINE DERIVATIVE OR SALT THEREOF | ASTELLAS PHARMA INC. (JP) | 2010-07-01 | — | — | US | disclosed |
| US-20080318937-A1 | TRICYCLIC DELTA-OPIOID MODULATORS | COATS STEVEN J | 2008-12-25 | — | — | US | disclosed |
| US-7432257-B2 | Piperdinyl-phenoxazine and phenothiazine derivatives as δ-opioid modulators | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-10-07 | — | — | US | disclosed |
| EP-1923387-A1 | ACYLGUANIDINE DERIVATIVE OR SALT THEREOF | Astellas Pharma Inc. (JP) | 2008-05-21 | — | — | EP | disclosed |
| US-20060148823-A1 | Tricyclic delta-opioid modulators | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-07-06 | — | — | US | disclosed |
| CN-1019299-B | Process for the preparation of 1-hydroxy-5-oxo-5H-pyrido [3, 2-a ] phenoxazine-3-carboxylic acid esters | SENJU PHARMA CO (JP) | 1992-12-02 | — | — | CN | disclosed |
| CN-87104927-A | The preparation method of 1-hydroxyl-5-oxo-5H-pyrido [3,2-a] fen piperazine-3-carboxylicesters | — | 1988-02-03 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060148823-A1 | Tricyclic delta-opioid modulators | OPRD1, OPRK1, OPRL1 | ALOX5 1363/4885HTR2B 409/4885HTR7 782/4885 |
| US-20080318937-A1 | TRICYCLIC DELTA-OPIOID MODULATORS | OPRD1, OPRK1, OPRL1 | ALOX5 1363/4885HTR2B 409/4885HTR7 782/4885 |
| US-20100168096-A1 | ACYLGUANIDINE DERIVATIVE OR SALT THEREOF | HTR2B, HTR7, HTR3B | ALOX5 540/4885HTR2B 1/4885HTR7 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.