Known targets — ChEMBL curated mechanism
ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO
The experimentally established mechanism targets of Water. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | DNM1 | Q05193 | 8/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Water SCHEMBL28648783 | 0.98 | CYP1A2 (0.31) | CYP1A2DNM1MEN1KMT2AALDH1A1 | |
| SCHEMBL4804565 | 0.97 | DNM1 (0.33) | CYP1A2DNM1MEN1KMT2AALDH1A1 | |
| SCHEMBL18080 | 0.97 | DNM1 (0.33) | CYP1A2DNM1MEN1KMT2AALDH1A1 | |
| SCHEMBL31287508 | 0.95 | CYP1A2 (0.32) | CYP1A2DNM1MEN1KMT2AALDH1A1 | |
| SCHEMBL31434647 | 0.95 | CYP1A2 (0.32) | CYP1A2DNM1MEN1KMT2AALDH1A1 | |
| Ammonia Solution, Strong SCHEMBL375640 | 0.95 | CYP1A2 (0.32) | CYP1A2DNM1MEN1KMT2AALDH1A1 | |
| SCHEMBL30782826 | 0.95 | CYP1A2 (0.32) | CYP1A2DNM1MEN1KMT2AALDH1A1 | |
| SCHEMBL19874458 | 0.95 | CYP1A2 (0.32) | CYP1A2DNM1MEN1KMT2AALDH1A1 | |
| SCHEMBL383533 | 0.95 | CYP1A2 (0.32) | CYP1A2DNM1MEN1KMT2AALDH1A1 | |
| SCHEMBL29286600 | 0.95 | CYP1A2 (0.32) | CYP1A2DNM1MEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113406324-B | S-shaped optical fiber cone immunosensor, preparation method and application thereof | 吉林大学 | 2023-01-24 | — | — | CN | claimed |
| CN-113406324-A | S-shaped optical fiber cone immunosensor, preparation method and application thereof | 吉林大学 | 2021-09-17 | — | — | CN | claimed |
| CN-109037624-A | A kind of flexible compound electrode and its battery of preparation | 郑州大学 | 2018-12-18 | — | — | CN | claimed |
| CN-108753573-A | The method for being captured in micro-fluidic chip and identifying fetal nucleated red blood | 武汉大学 | 2018-11-06 | — | — | CN | claimed |
| CN-118024369-A | Flame-retardant wood board with high dimensional stability and preparation and application thereof | 韩师傅集成家居有限公司 | 2024-05-14 | — | — | CN | disclosed |
| CN-113406324-B | S-shaped optical fiber cone immunosensor, preparation method and application thereof | 吉林大学 | 2023-01-24 | — | — | CN | disclosed |
| CN-113406324-A | S-shaped optical fiber cone immunosensor, preparation method and application thereof | 吉林大学 | 2021-09-17 | — | — | CN | disclosed |
| EP-0958046-B1 | CELL SEPARATION COMPOSITION, KIT AND METHOD | DENDREON CORP (US) | 2011-10-26 | — | — | EP | disclosed |