Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
| ▸ | CASP7 | P55210 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | AHR | P35869 | 2/20 | 0.32 |
| ▸ | TSHR | P16473 | 3/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.32 |
| ▸ | MAOA | P21397 | 2/20 | 0.32 |
| ▸ | MAOB | P27338 | 2/20 | 0.32 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL367855 | 0.77 | TRPA1 (0.52) | ALDH1A1KDM4EMEN1MAPTKMT2A | |
| SCHEMBL18585518 | 0.76 | ALDH1A1 (0.39) | ALDH1A1KDM4EMEN1MAPTKMT2A | |
| SCHEMBL1127657 | 0.75 | TRPA1 (0.39) | ALDH1A1KDM4EMEN1MAPTKMT2A | |
| SCHEMBL1127756 | 0.75 | TRPA1 (0.39) | ALDH1A1KDM4EMEN1MAPTKMT2A | |
| SCHEMBL1128324 | 0.75 | AHR (0.50) | ALDH1A1KDM4EMEN1MAPTKMT2A | |
| SCHEMBL1127529 | 0.75 | TRPA1 (0.39) | ALDH1A1KDM4EMEN1MAPTKMT2A | |
| SCHEMBL1127937 | 0.75 | TRPA1 (0.39) | ALDH1A1KDM4EMEN1MAPTKMT2A | |
| SCHEMBL4749318 | 0.74 | TRPA1 (0.50) | ALDH1A1KDM4EMEN1MAPTKMT2A | |
| SCHEMBL1275953 | 0.72 | MAPK1 (0.37) | ALDH1A1KDM4EMEN1MAPTKMT2A | |
| SCHEMBL3192100 | 0.71 | ALDH1A1 (0.48) | ALDH1A1KDM4EMEN1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8034900-B2 | Water-soluble thioester and selenoester compounds and methods for making and using the same | AMYLIN PHARMACEUTICALS, INC. (US) | 2011-10-11 | — | — | US | disclosed |
| US-7759302-B2 | Octapeptides: Arg-X-Asp-Leu-Asp-Ser-Leu-Arg where X is a 2-aminoaulfonylaminoalkanoic acid and optionally having various end groups; biologically active as ligands of blood platelet integrin GPIIbIIIa and the alpha v integrins | MERCK PATENT GMBH (DE) | 2010-07-20 | — | — | US | disclosed |
| EP-1631597-A4 | DISPLACEABLE LINKER SOLID PHASE CHEMICAL LIGATION | GRYPHON THERAPEUTICS INC (US) | 2007-07-11 | — | — | EP | disclosed |
| EP-1616003-A4 | WATER-SOLUBLE THIOESTER AND SELENOESTER COMPOUNDS AND METHODS FOR MAKING AND USING THE SAME | GRYPHON THERAPEUTICS INC (US) | 2007-06-20 | — | — | EP | disclosed |
| US-20060275768-A1 | Multiplex polymer ligation | AMYLIN PHARMACEUTICALS, INC. | 2006-12-07 | — | — | US | disclosed |
| EP-1616021-A4 | MULTIPLEX POLYMER LIGATION | GRYPHON THERAPEUTICS INC (US) | 2006-08-30 | — | — | EP | disclosed |
| US-20060173159-A1 | Water-soluble thioester and selenoester compounds and methods for making and using the same | ASTRAZENECA PHARMACEUTICALS LP | 2006-08-03 | — | — | US | disclosed |
| US-20060148716-A1 | Peptidic sulfonamides | MERCK PATENT GMBH (DE) | 2006-07-06 | — | — | US | disclosed |
| EP-1631597-A2 | DISPLACEABLE LINKER SOLID PHASE CHEMICAL LIGATION | Gryphon Therapeutics, Inc. (US) | 2006-03-08 | — | — | EP | disclosed |
| EP-1616021-A2 | MULTIPLEX POLYMER LIGATION | Gryphon Therapeutics, Inc. (US) | 2006-01-18 | — | — | EP | disclosed |
| EP-1616003-A1 | WATER-SOLUBLE THIOESTER AND SELENOESTER COMPOUNDS AND METHODS FOR MAKING AND USING THE SAME | Gryphon Therapeutics, Inc. (US) | 2006-01-18 | — | — | EP | disclosed |
| WO-2004105685-A2 | DISPLACEABLE LINKER SOLID PHASE CHEMICAL LIGATION | GRYPHON THERAPEUTICS, INC. (US) | 2004-12-09 | — | — | WO | disclosed |
| WO-2004061094-A1 | WATER-SOLUBLE THIOESTER AND SELENOESTER COMPOUNDS AND METHODS FOR MAKING AND USING THE SAME | GRYPHON THERAPEUTICS, INC. (US) | 2004-07-22 | — | — | WO | disclosed |
| WO-2004060925-A2 | MULTIPLEX POLYMER LIGATION | GRYPHON THERAPEUTICS, INC. (US) | 2004-07-22 | — | — | WO | disclosed |
| WO-2004060863-A2 | BACKBONE ANCHORED THIOESTER AND SELENOESTER GENERATORS | GRYPHON THERAPEUTICS, INC. (US) | 2004-07-22 | — | — | WO | disclosed |
| US-20040132966-A1 | Backbone anchored thioester and selenoester generators | GRYPHON THERAPEUTICS, INC. | 2004-07-08 | — | — | US | disclosed |
| US-20040063902-A1 | Side chain anchored thioester and selenoester generators | GRYPHON THERAPEUTICS, INC. | 2004-04-01 | — | — | US | disclosed |
| WO-2004011424-A2 | SIDE CHAIN ANCHORED THIOESTER AND SELENOESTER GENERATORS | GRYPHON THERAPEUTICS, INC. (US) | 2004-02-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040132966-A1 | Backbone anchored thioester and selenoester generators | SCLY, SELENOI, ETF1 | ALDH1A1 3705/4885KDM4E 4692/4885MEN1 1794/4885 |
| US-20060148716-A1 | Peptidic sulfonamides | ITGB3, ITGA2B, ITGA2 | ALDH1A1 3369/4885KDM4E 3965/4885MEN1 4668/4885 |
| US-20060173159-A1 | Water-soluble thioester and selenoester compounds and methods for making and using the same | SCLY, TST, SELENOI | ALDH1A1 2859/4885KDM4E 3297/4885MEN1 2151/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.