Sugi Predict

Sugi Predict / Compounds / SCHEMBL251656

SCHEMBL251656

SCHEMBL251656

N=C(c1ccc(N)cc1)c1ccc(N)cc1

nearest known ligand 0.65

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ PLAU P00749 2/20 0.65
▸ MASP2 O00187 1/20 0.65
▸ THPO P40225 1/20 0.65
▸ APEX1 P27695 2/20 0.62
▸ F2 P00734 1/20 0.62
▸ PRSS1 P07477 1/20 0.62
▸ PRSS3 P35030 1/20 0.62
▸ MAPT P10636 2/20 0.50
▸ MEN1 O00255 2/20 0.50
▸ KMT2A Q03164 2/20 0.50
▸ CYP19A1 P11511 3/20 0.46
▸ CYP3A4 P08684 6/20 0.45
▸ ALDH1A1 P00352 4/20 0.45
▸ HIF1A Q16665 3/20 0.45
▸ ALOX15 P16050 3/20 0.45
▸ HSD17B10 Q99714 2/20 0.45
▸ CA3 P07451 1/20 0.45
▸ THRB P10828 1/20 0.45
▸ CA6 P23280 1/20 0.45
▸ CASP1 P29466 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10778018 0.89 MASP2 (0.54) PLAUMASP2THPOAPEX1F2
SCHEMBL150756 0.79 PLAU (1.00) PLAUMASP2THPOAPEX1F2
SCHEMBL18480045 0.77 PLAU (0.59) PLAUMASP2THPOAPEX1F2
Hydrochloric Acid SCHEMBL236095 0.77 PRSS1 (1.00) PLAUMASP2THPOAPEX1F2
Hydrochloric Acid SCHEMBL538862 0.77 PRSS1 (1.00) PLAUMASP2THPOAPEX1F2
SCHEMBL9692808 0.77 PLAU (0.46) PLAUMASP2THPOAPEX1F2
SCHEMBL10493685 0.73 MAPT (0.57) PLAUMASP2THPOAPEX1F2
SCHEMBL10933735 0.73 CYP19A1 (0.65) PLAUMASP2THPOAPEX1F2
SCHEMBL4619841 0.73 PLAU (0.54) PLAUMASP2THPOAPEX1F2
SCHEMBL11839172 0.73 PLAU (0.54) PLAUMASP2THPOAPEX1F2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 530 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8076072-B2 Nucleic acid labeling compounds AFFYMETRIX, INC. (US) 2011-12-13 — — US claimed
US-8026057-B2 Nucleic acid labeling compounds AFFYMETRIX, INC. (US) 2011-09-27 — — US claimed
US-7468243-B2 Nucleotide sequence labelling compoumd four use as tool in genetic engineering AFFYMETRIX, INC. (US) 2008-12-23 — — US claimed
US-7291463-B2 Incubating/condensating pseudoisocytidine molecule with (1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride to provide a pseudouridine molecule; oncology diagnosis AFFYMETRIX, INC. (US) 2007-11-06 — — US claimed
US-7282327-B2 Nucleic acid labeling compounds AFFYMETRIX, INC. (US) 2007-10-16 — — US claimed
US-12043869-B2 Compositions and methods for detecting predisposition to cardiovascular disease UNIVERSITY OF IOWA RESEARCH FOUNDATION (US) 2024-07-23 — — US disclosed
US-11993772-B2 Linking sequence reads using paired code tags ILLUMINA, INC. (US) 2024-05-28 — — US disclosed
US-20230406874-A1 FUNCTIONALIZATION AND PURIFICATION OF MOLECULES BY REVERSIBLE GROUP EXCHANGE ILLUMINA, INC. 2023-12-21 — — US disclosed
US-20230313302-A1 METHODS AND COMPOSITIONS FOR PREDICTING AND/OR MONITORING DIABETES AND TREATMENTS THEREFOR Cardio Diagnostics, Inc. 2023-10-05 — — US disclosed
US-11760772-B2 Functionalization and purification of molecules by reversible group exchange ILLUMINA, INC. (US) 2023-09-19 — — US disclosed
EP-4208571-A1 METHODS AND COMPOSITIONS FOR PREDICTING AND/OR MONITORING DIABETES AND TREATMENTS THEREFOR University of Iowa Research Foundation (US) 2023-07-12 — — EP disclosed
US-20230008544-A1 COMPOSITIONS AND METHODS FOR DETECTING PREDISPOSITION TO CARDIOVASCULAR DISEASE UNIVERSITY OF IOWA RESEARCH FOUNDATION 2023-01-12 — — US disclosed
US-4272506-A BINDING A LABELED MEMBER OF A SPECIFIC BINDING PAIR TO A MERCAPTO-ACTIVATED SUPPORT THROUGH CLEAVABLE DISULFIDE LINKAGES; IMMUNOASSAY; ACCURACY SYVA COMPANY (US) 1981-06-09 — — US disclosed
US-4256834-A REPRESSING THE SIGNALS PRODUCED BY UNBOUND LABELS; SENSITIVITY SYVA COMPANY (US) 1981-03-17 — — US disclosed
WO-1981000261-A1 CHARGE EFFECTS IN IMMUNOASSAYS SYVA CO (US) 1981-02-05 — — WO disclosed
EP-0022768-A1 MACROMOLECULAR ENVIRONMENT CONTROL IN SPECIFIC RECEPTOR ASSAYS. SYVA CO (US) 1981-01-28 — — EP disclosed
EP-0017908-A1 A method for determining the presence in a sample of an analyte and a kit for use in this method SYVA COMPANY (US) 1980-10-29 — — EP disclosed
EP-0022768-A4 MACROMOLECULAR ENVIRONMENT CONTROL IN SPECIFIC RECEPTOR ASSAYS. SYVA CO (US) 1980-08-18 — — EP disclosed
US-4193983-A Labeled liposome particle compositions and immunoassays therewith SYVA COMPANY (US) 1980-03-18 — — US disclosed
WO-1979000882-A1 MACROMOLECULAR ENVIRONMENT CONTROL IN SPECIFIC RECEPTOR ASSAYS SYVA CO (US) 1979-11-01 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230406874-A1 FUNCTIONALIZATION AND PURIFICATION OF MOLECULES BY REVERSIBLE GROUP EXCHANGE PHAX, ALKBH1, JMJD6 PLAU 1180/4885MASP2 2753/4885THPO 3450/4885
US-11760772-B2 Functionalization and purification of molecules by reversible group exchange PHAX, ALKBH1, JMJD6 PLAU 1180/4885MASP2 2753/4885THPO 3450/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.