Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRSS1 | P07477 | 5/20 | 1.00 |
| ▸ | F2 | P00734 | 4/20 | 1.00 |
| ▸ | PRSS3 | P35030 | 4/20 | 1.00 |
| ▸ | APEX1 | P27695 | 1/20 | 1.00 |
| ▸ | PLAU | P00749 | 3/20 | 0.94 |
| ▸ | MASP2 | O00187 | 1/20 | 0.94 |
| ▸ | THPO | P40225 | 1/20 | 0.94 |
| ▸ | LMNA | P02545 | 2/20 | 0.61 |
| ▸ | BLM | P54132 | 1/20 | 0.59 |
| ▸ | PRSS2 | P07478 | 3/20 | 0.56 |
| ▸ | C1S | P09871 | 1/20 | 0.56 |
| ▸ | RECQL | P46063 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | F10 | P00742 | 2/20 | 0.55 |
| ▸ | F12 | P00748 | 1/20 | 0.55 |
| ▸ | F7 | P08709 | 1/20 | 0.55 |
| ▸ | F3 | P13726 | 1/20 | 0.55 |
| ▸ | PKM | P14618 | 1/20 | 0.55 |
| ▸ | ST14 | Q9Y5Y6 | 1/20 | 0.54 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL538862 | 1.00 | PRSS1 (1.00) | PRSS1F2PRSS3APEX1PLAU | |
| Hydrochloric Acid SCHEMBL28256621 | 0.97 | PRSS1 (0.95) | PRSS1F2PRSS3APEX1PLAU | |
| SCHEMBL150756 | 0.97 | PLAU (1.00) | PRSS1F2PRSS3APEX1PLAU | |
| Ammonia Solution, Strong SCHEMBL28058272 | 0.94 | PLAU (0.94) | PRSS1F2PRSS3APEX1PLAU | |
| Hydrochloric Acid SCHEMBL30999366 | 0.88 | PRSS1 (0.78) | PRSS1F2PRSS3APEX1PLAU | |
| Hydrochloric Acid SCHEMBL392375 | 0.88 | PRSS1 (0.78) | PRSS1F2PRSS3APEX1PLAU | |
| Carbamic Acid SCHEMBL28064780 | 0.87 | PLAU (0.81) | PRSS1F2PRSS3APEX1PLAU | |
| SCHEMBL537030 | 0.85 | LMNA (0.77) | PRSS1F2PRSS3APEX1PLAU | |
| Acetic Acid SCHEMBL7398032 | 0.84 | MASP2 (0.74) | PRSS1F2PRSS3APEX1PLAU | |
| Hydrochloric Acid SCHEMBL29182280 | 0.80 | PRSS1 (0.67) | PRSS1F2PRSS3APEX1PLAU |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 323 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116769385-B | Anti-cracking anticorrosive paint and preparation method thereof | 广东省漆色彩新型材料有限公司 | 2024-04-26 | — | — | CN | claimed |
| CN-116769385-A | Anti-cracking anticorrosive paint and preparation method thereof | 广东蓝风环境科技服务有限公司 | 2023-09-19 | — | — | CN | claimed |
| CN-115385823-A | Preparation method of 4-aminobenzamidine dihydrochloride | 四川青木制药有限公司 | 2022-11-25 | — | — | CN | claimed |
| CN-111957073-B | Affinity chromatography filler for purifying urokinase, preparation method and application | 武汉人福药业有限责任公司 | 2021-12-24 | — | — | CN | claimed |
| CN-109052602-B | Natural polymeric flocculant for starch wastewater treatment and treatment method thereof | 南京大学 | 2021-04-23 | — | — | CN | claimed |
| CN-111957073-A | Affinity chromatography filler for purifying urokinase, preparation method and application | 武汉人福药业有限责任公司 | 2020-11-20 | — | — | CN | claimed |
| CN-111606885-A | Dabigatran etexilate mesylate and preparation method thereof | 安徽鼎旺医药有限公司 | 2020-09-01 | — | — | CN | claimed |
| CN-109836412-A | A kind of preparation method of dabigatran etexilate methanesulfonate | 辽宁博美医药科技有限公司 | 2019-06-04 | — | — | CN | claimed |
| CN-109052602-A | A kind of natural macromolecule flocculating agent and its processing method for starch wastewater treatment | 南京大学 | 2018-12-21 | — | — | CN | claimed |
| CN-106083822-B | A kind of preparation method of dabigatran etexilate methanesulfonate intermediate | 本溪经济开发区博美医药新技术开发有限公司 | 2018-09-11 | — | — | CN | claimed |
| CN-104610096-A | Diminazene aceturate production method | HENAN LINGXIAN PHARMACEUTICAL CO LTD | 2015-05-13 | — | — | CN | claimed |
| CN-101970676-A | Compositions for forming immobiized biological layers for sensing | ABBOTT POINT OF CARE INC | 2011-02-09 | — | — | CN | claimed |
| EP-1750743-A4 | ORAL FORMULATIONS COMPRISING BONE MORPHOGENETIC PROTEINS FOR TREATING METABOLIC BONE DISEASES | GLAXOSMITHKLINE ZAGREB (HR) | 2009-07-08 | — | — | EP | claimed |
| US-20070265187-A1 | Oral Formulations Comprising Bone Morphogenetic Proteins For Treating Metabolic Bone Diseases | GLAXOSMITHKLINE ISTRAZIVACKI CENTAR ZAGREB D.O.O. ZA ISTRAZIVANJE I RAZVOJ (HR) | 2007-11-15 | — | — | US | claimed |
| EP-1750743-A2 | ORAL FORMULATIONS COMPRISING BONE MORPHOGENETIC PROTEINS FOR TREATING METABOLIC BONE DISEASES | GlaxoSmithKline istrazivacki centar Zagreb d.o.o. (HR) | 2007-02-14 | — | — | EP | claimed |
| WO-2005110465-A2 | ORAL FORMULATIONS COMPRISING BONE MORPHOGENETIC PROTEINS FOR TREATING METABOLIC BONE DISEASES | GLAXOSMITHKLINE ISTRAZIVACKI CENTAR ZAGREB D.O.O. (HR) | 2005-11-24 | — | — | WO | claimed |
| EP-0839128-B1 | PROCESS FOR THE PREPARATION OF ETHYL 3S-[[4-[[4-(AMINOIMINOMETHYL)PHENYL]AMINO]-1,4-DIOXOBUTYL]AMINO]-4-PENTYNOATE | SEARLE & CO (US) | 2000-04-05 | — | — | EP | claimed |
| EP-0839128-A1 | PROCESS FOR THE PREPARATION OF ETHYL 3S-[[4-[[4-(AMINOIMINOMETHYL)PHENYL]AMINO]-1,4-DIOXOBUTYL]AMINO]-4-PENTYNOATE | G.D. SEARLE & CO. (US) | 1998-05-06 | — | — | EP | claimed |
| WO-1997003947-A1 | PROCESS FOR THE PREPARATION OF ETHYL 3S-[[4-[[4-(AMINOIMINOMETHYL)PHENYL]AMINO]-1,4-DIOXOBUTYL]AMINO]-4-PENTYNOATE | G.D. SEARLE & CO. (US) | 1997-02-06 | — | — | WO | claimed |
| US-5536869-A | Process for the preparation of ethyl 3S-[4-[[4-(aminoiminomethyl)phenyl]amino]-1,4-dioxobutyl]amino]-4-pentynoate | G. D. SEARLE & CO. (US) | 1996-07-16 | — | — | US | claimed |