SCHEMBL252005

SCHEMBL252005

C=CCn1nnnc1C(=O)c1ccccc1

nearest known ligand 0.42

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
HSD11B1 P28845 4/20 0.42
ALDH1A1 P00352 5/20 0.40
LMNA P02545 2/20 0.40
HPGD P15428 1/20 0.40
RAB9A P51151 3/20 0.39
TSHR P16473 1/20 0.39
SMN1; SMN2 Q16637 3/20 0.38
HRH1 P35367 1/20 0.38
HDAC6 Q9UBN7 1/20 0.38
MEN1 O00255 1/20 0.38
NPC1 O15118 1/20 0.38
KMT2A Q03164 1/20 0.38
RECQL P46063 1/20 0.36
KDM4C Q9H3R0 1/20 0.36
AKT1 P31749 1/20 0.36
L3MBTL1 Q9Y468 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15170828 0.81 RAB9A (0.38) HSD11B1ALDH1A1LMNAHPGDRAB9A
SCHEMBL15170827 0.81 RAB9A (0.38) HSD11B1ALDH1A1LMNAHPGDRAB9A
SCHEMBL11790464 0.80 KDM4C (0.51) HSD11B1ALDH1A1LMNAHPGDRAB9A
SCHEMBL4686925 0.80 ALDH1A1 (0.44) HSD11B1ALDH1A1LMNARAB9ATSHR
SCHEMBL16550566 0.79 ALDH1A1 (0.57) ALDH1A1LMNAHPGDRAB9ATSHR
SCHEMBL5504671 0.77 HSD11B1 (0.46) HSD11B1ALDH1A1LMNAHPGDRAB9A
SCHEMBL5139103 0.70 RAB9A (0.62) HSD11B1ALDH1A1LMNAHPGDRAB9A
SCHEMBL5702291 0.70 MAPK14 (0.43) ALDH1A1LMNAHPGDRAB9AHRH1
SCHEMBL7696677 0.69 MAPK14 (0.43) ALDH1A1LMNAHPGDRAB9ASMN1; SMN2
Benzophenone SCHEMBL28043630 0.68 CYP3A4 (0.57) ALDH1A1LMNAHPGDRAB9ATSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 42 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2407461-B1 PROCESS FOR PREPARATION OF 1-ALKYL-5-BENZOYL-1H-TETRAZOLE DERIVATIVES NIPPON SODA CO (JP) 2016-05-18 EP claimed
CN-102341378-B The preparation method of 1-alkyl-5-benzoyl-1H-TETRAZOLE derivative NIPPON SODA CO.,LTD. (JP) 2015-09-09 CN claimed
US-8273781-B2 Process for preparation of 1-alkyl-5-benzoyl-1H-tetrazole derivatives NIPPON SODA CO., LTD. (JP) 2012-09-25 US claimed
CN-102341378-A PROCESS FOR PREPARATION OF 1-ALKYL-5-BENZOYL-1H-TETRAZOLE DERIVATIVES NIPPON SODA CO 2012-02-01 CN claimed
EP-2407461-A1 PROCESS FOR PREPARATION OF 1-ALKYL-5-BENZOYL-1H-TETRAZOLE DERIVATIVES Nippon Soda Co., Ltd. (JP) 2012-01-18 EP claimed
US-20120004420-A1 PROCESS FOR PREPARATION OF 1-ALKYL-5-BENZOYL-1H-TETRAZOLE DERIVATIVES NIPPON SODA CO., LTD. (JP) 2012-01-05 US claimed
EP-2860173-B1 METHOD FOR PRODUCING AZIDE COMPOUND, AND METHOD FOR PRODUCING 1H-TETRAZOLE DERIVATIVE NIPPON SODA CO (JP) 2021-05-05 EP disclosed
CN-104350038-B Method for producing azide compound and method for producing 1H-tetrazole derivative 日本曹达株式会社 2017-05-24 CN disclosed
CN-104350043-B Method for producing 1h-tetrazole derivative 日本曹达株式会社 2017-05-03 CN disclosed
US-9630933-B2 Method for producing 1-H-tetrazole derivative NIPPON SODA CO., LTD. (JP) 2017-04-25 US disclosed
EP-2845853-B1 METHOD FOR PRODUCING 1H-TETRAZOLE DERIVATIVE NIPPON SODA CO (JP) 2017-01-25 EP disclosed
EP-2826773-B1 COMPOUND, METHOD FOR PRODUCING COMPOUND, AND METHOD FOR PURIFYING COMPOUND NIPPON SODA CO (JP) 2016-11-02 EP disclosed
CN-104610091-B A kind of method purifying N-toluyl crude formamide 北京颖泰嘉和生物科技股份有限公司 2016-09-21 CN disclosed
CN-102341378-A PROCESS FOR PREPARATION OF 1-ALKYL-5-BENZOYL-1H-TETRAZOLE DERIVATIVES NIPPON SODA CO 2012-02-01 CN disclosed
CN-102341378-A PROCESS FOR PREPARATION OF 1-ALKYL-5-BENZOYL-1H-TETRAZOLE DERIVATIVES NIPPON SODA CO 2012-02-01 CN disclosed
EP-2407461-A1 PROCESS FOR PREPARATION OF 1-ALKYL-5-BENZOYL-1H-TETRAZOLE DERIVATIVES Nippon Soda Co., Ltd. (JP) 2012-01-18 EP disclosed
EP-2407461-A1 PROCESS FOR PREPARATION OF 1-ALKYL-5-BENZOYL-1H-TETRAZOLE DERIVATIVES Nippon Soda Co., Ltd. (JP) 2012-01-18 EP disclosed
US-20120004420-A1 PROCESS FOR PREPARATION OF 1-ALKYL-5-BENZOYL-1H-TETRAZOLE DERIVATIVES NIPPON SODA CO., LTD. (JP) 2012-01-05 US disclosed
US-20120004420-A1 PROCESS FOR PREPARATION OF 1-ALKYL-5-BENZOYL-1H-TETRAZOLE DERIVATIVES NIPPON SODA CO., LTD. (JP) 2012-01-05 US disclosed
WO-2010103783-A1 PROCESS FOR PREPARATION OF 1-ALKYL-5-BENZOYL-1H-TETRAZOLE DERIVATIVES 日本曹達株式会社 (JP) 2010-09-16 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120004420-A1 PROCESS FOR PREPARATION OF 1-ALKYL-5-BENZOYL-1H-TETRAZOLE DERIVATIVES KCNMA1, KCNA5, KCNK5 HSD11B1 1608/4885ALDH1A1 546/4885LMNA 1059/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.