Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS1 | P29475 | 2/20 | 0.34 |
| ▸ | NOS3 | P29474 | 1/20 | 0.34 |
| ▸ | NOS2 | P35228 | 1/20 | 0.34 |
| ▸ | DPP4 | P27487 | 2/20 | 0.32 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25201507 | 1.00 | NOS1 (0.34) | NOS1NOS3NOS2DPP4CHRM2 | |
| SCHEMBL26091132 | 0.85 | CHRM2 (0.42) | NOS1NOS3NOS2DPP4CHRM2 | |
| SCHEMBL26091128 | 0.85 | CHRM2 (0.42) | NOS1NOS3NOS2DPP4CHRM2 | |
| SCHEMBL8487787 | 0.84 | DPP4 (0.40) | NOS1NOS3NOS2DPP4CHRM2 | |
| SCHEMBL3187231 | 0.84 | DPP4 (0.40) | NOS1NOS3NOS2DPP4CHRM2 | |
| SCHEMBL14978004 | 0.82 | DPP4 (0.36) | NOS1NOS3NOS2DPP4CHRM2 | |
| SCHEMBL31564804 | 0.82 | DPP4 (0.36) | NOS1NOS3NOS2DPP4CHRM2 | |
| SCHEMBL27570839 | 0.79 | DPP4 (0.41) | DPP4 | |
| SCHEMBL12374491 | 0.78 | DPP4 (0.44) | DPP4 | |
| SCHEMBL4116106 | 0.78 | NOS1 (0.34) | NOS1NOS3NOS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250019376-A1 | CHROMANE AMIDINE MONOBACTAM ANTIBIOTICS | MERCK SHARP & DOHME LLC (US) | 2025-01-16 | — | — | US | disclosed |
| EP-4433476-A1 | CHROMANE AMIDINE MONOBACTAM ANTIBIOTICS | Merck Sharp & Dohme LLC (US) | 2024-09-25 | — | — | EP | disclosed |
| CN-118265711-A | Chromanamidine monocyclic lactam antibiotics | 默沙东有限责任公司 | 2024-06-28 | — | — | CN | disclosed |
| US-11932637-B2 | Chromane amidine monobactam compounds for the treatment of bacterial infections | MERCK SHARP & DOHME LLC (US) | 2024-03-19 | — | — | US | disclosed |
| US-20230159517-A1 | CHROMANE AMIDINE MONOBACTAM COMPOUNDS FOR THE TREATMENT OF BACTERIAL INFECTIONS | MERCK SHARP & DOHME LLC (US) | 2023-05-25 | — | — | US | disclosed |
| WO-2023091438-A1 | CHROMANE AMIDINE MONOBACTAM ANTIBIOTICS | MERCK SHARP & DOHME LLC (US) | 2023-05-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230159517-A1 | CHROMANE AMIDINE MONOBACTAM COMPOUNDS FOR THE TREATMENT OF BACTERIAL INFECTIONS | TCOF1, SLC10A2, PAM | NOS1 1926/4885NOS3 2961/4885NOS2 2124/4885 |
| US-20250019376-A1 | CHROMANE AMIDINE MONOBACTAM ANTIBIOTICS | PAM, ACMSD, MGAM2 | NOS1 976/4885NOS3 2182/4885NOS2 1288/4885 |
| US-11932637-B2 | Chromane amidine monobactam compounds for the treatment of bacterial infections | MGAM, MGAM2, ELANE | NOS1 665/4885NOS3 1893/4885NOS2 713/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.