⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL149146 | 0.77 | POLB (0.38) | — | |
| SCHEMBL6245968 | 0.77 | NOS3 (0.33) | — | |
| SCHEMBL1852682 | 0.77 | NOS3 (0.33) | — | |
| SCHEMBL6665323 | 0.77 | ALDH1A1 (0.35) | — | |
| SCHEMBL5618639 | 0.76 | POLB (0.37) | — | |
| SCHEMBL1853569 | 0.76 | ALDH1A1 (0.34) | — | |
| Methane SCHEMBL30958396 | 0.76 | ALDH1A1 (0.40) | — | |
| SCHEMBL6670962 | 0.74 | GABRP (0.41) | — | |
| SCHEMBL930036 | 0.74 | KDM4D (0.34) | — | |
| SCHEMBL2514613 | 0.72 | CYP2D6 (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8034938-B2 | Imidazo[4,5-c]quinolines, 6,7,8,9-tetrahydroimidazo[4,5-c]quinolines, imidazo[4,5-c]naphthyridines, and 6,7,8,9-tetrahydroimidazo[4,5-c]naphthyridines) with a CH( R1) group in the fused ring at 1-position of imidazo ring; modulate immune response, by induction of cytokine biosynthesis or other mechanism | 3M INNOVATIVE PROPERTIES COMPANY (US) | 2011-10-11 | — | — | US | disclosed |