Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JUN | P05412 | 1/20 | 0.56 |
| ▸ | ELANE | P08246 | 5/20 | 0.50 |
| ▸ | CTSG | P08311 | 4/20 | 0.50 |
| ▸ | SLC37A4 | O43826 | 2/20 | 0.48 |
| ▸ | MAOA | P21397 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | TSHR | P16473 | 3/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | RECQL | P46063 | 2/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28933782 | 0.93 | SLC37A4 (0.57) | JUNELANECTSGSLC37A4MAOA | |
| Bromide SCHEMBL29191320 | 0.76 | SLC37A4 (0.39) | JUNELANECTSGSLC37A4MAOA | |
| SCHEMBL16916988 | 0.76 | MAOA (0.53) | JUNELANECTSGSLC37A4MAOA | |
| SCHEMBL29077765 | 0.74 | ALDH1A1 (0.43) | JUNELANECTSGSLC37A4MAOA | |
| SCHEMBL2314224 | 0.73 | JUN (0.69) | JUNELANECTSGSLC37A4MAOA | |
| SCHEMBL16431884 | 0.72 | JUN (1.00) | JUNELANECTSGSLC37A4MAOA | |
| SCHEMBL16916989 | 0.71 | MAOA (0.54) | JUNELANECTSGMAOAALDH1A1 | |
| Lupinacidin B SCHEMBL29884252 | 0.71 | ELANE (0.61) | JUNELANECTSGSLC37A4MAOA | |
| SCHEMBL8996324 | 0.71 | FTO (0.68) | JUNELANECTSGMAOAALDH1A1 | |
| SCHEMBL30695844 | 0.70 | MAOA (0.86) | ELANECTSGMAOAALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113999136-B | Rhein derivative, preparation method and application thereof, and liver cancer inhibitor specifically expressed by RECQL4 | 山东第一医科大学(山东省医学科学院) | 2023-08-04 | — | — | CN | disclosed |
| US-20230174497-A1 | RHEIN AMIDE DERIVATIVE AND PREPARATION METHOD AND USE THEREOF, AND INHIBITOR OF HEPATOCELLULAR CARCINOMA (HCC) WITH SPECIFIC RECQL4 EXPRESSION | Shandong First Medical University & Shandong Academy Of Medical Sciences (CN) | 2023-06-08 | — | — | US | disclosed |
| CN-113999136-A | Rheum officinale amide derivative, preparation method and application thereof, and liver cancer inhibitor specifically expressed by RECQL4 | 山东第一医科大学(山东省医学科学院) | 2022-02-01 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230174497-A1 | RHEIN AMIDE DERIVATIVE AND PREPARATION METHOD AND USE THEREOF, AND INHIBITOR OF HEPATOCELLULAR CARCINOMA (HCC) WITH SPECIFIC RECQL4 EXPRESSION | RECQL, MRTO4, SNU13 | JUN 4675/4885ELANE 4057/4885CTSG 4760/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.