Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JUN | P05412 | 1/20 | 0.69 |
| ▸ | FTO | Q9C0B1 | 2/20 | 0.60 |
| ▸ | ELANE | P08246 | 8/20 | 0.60 |
| ▸ | CTSG | P08311 | 7/20 | 0.60 |
| ▸ | SLC37A4 | O43826 | 3/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | TSHR | P16473 | 3/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.53 |
| ▸ | RECQL | P46063 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | HPGD | P15428 | 2/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.53 |
| ▸ | TTR | P02766 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16431884 | 0.81 | JUN (1.00) | JUNFTOELANECTSGSLC37A4 | |
| SCHEMBL5981442 | 0.81 | FTO (0.68) | JUNFTOELANECTSGSLC37A4 | |
| Anthraquinone SCHEMBL3670422 | 0.80 | JUN (0.95) | JUNFTOELANECTSGSLC37A4 | |
| SCHEMBL16431803 | 0.76 | ELANE (0.62) | JUNFTOELANECTSGSLC37A4 | |
| SCHEMBL28319049 | 0.74 | SLC37A4 (0.51) | JUNFTOELANESLC37A4ALDH1A1 | |
| SCHEMBL23723959 | 0.74 | FTO (0.73) | JUNFTOELANECTSGSLC37A4 | |
| SCHEMBL25211546 | 0.73 | JUN (0.56) | JUNFTOELANECTSGSLC37A4 | |
| SCHEMBL17867433 | 0.73 | ELANE (0.62) | JUNFTOELANECTSGSLC37A4 | |
| SCHEMBL16431638 | 0.73 | ELANE (0.67) | JUNFTOELANECTSGSLC37A4 | |
| Rhein SCHEMBL1356821 | 0.72 | ALDH1A1 (0.97) | JUNFTOELANEALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8951992-B2 | Mycobacterium membrane protease as a target for inhibitors of intrabacterial pH homeostasis | CORNELL UNIVERSITY (US) | 2015-02-10 | — | — | US | disclosed |
| US-8951992-B2 | Mycobacterium membrane protease as a target for inhibitors of intrabacterial pH homeostasis | CORNELL UNIVERSITY (US) | 2015-02-10 | — | — | US | disclosed |
| US-8951992-B2 | Mycobacterium membrane protease as a target for inhibitors of intrabacterial pH homeostasis | CORNELL UNIVERSITY (US) | 2015-02-10 | — | — | US | disclosed |
| US-20110190234-A1 | MYCOBACTERIUM MEMBRANE PROTEASE AS A TARGET FOR INHIBITORS OF INTRABACTERIAL pH HOMEOSTASIS | CORNELL UNIVERSITY (US) | 2011-08-04 | — | — | US | disclosed |
| US-20110190234-A1 | MYCOBACTERIUM MEMBRANE PROTEASE AS A TARGET FOR INHIBITORS OF INTRABACTERIAL pH HOMEOSTASIS | CORNELL UNIVERSITY (US) | 2011-08-04 | — | — | US | disclosed |
| US-20110190234-A1 | MYCOBACTERIUM MEMBRANE PROTEASE AS A TARGET FOR INHIBITORS OF INTRABACTERIAL pH HOMEOSTASIS | CORNELL UNIVERSITY (US) | 2011-08-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110190234-A1 | MYCOBACTERIUM MEMBRANE PROTEASE AS A TARGET FOR INHIBITORS OF INTRABACTERIAL pH HOMEOSTASIS | PREP, AFG3L2, TMPRSS15 | JUN 1752/4885FTO 4885/4885ELANE 514/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.