Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE1A | P54750 | 3/20 | 0.54 |
| ▸ | PDE1B | Q01064 | 3/20 | 0.54 |
| ▸ | PDE1C | Q14123 | 3/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.53 |
| ▸ | CMA1 | P23946 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | RGS4 | P49798 | 2/20 | 0.48 |
| ▸ | DCTPP1 | Q9H773 | 2/20 | 0.47 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.47 |
| ▸ | GSK3A | P49840 | 1/20 | 0.46 |
| ▸ | GSK3B | P49841 | 1/20 | 0.46 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | GFER | P55789 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | RGS8 | P57771 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27171716 | 0.75 | PDE1B (0.50) | PDE1APDE1BPDE1CALDH1A1MAPT | |
| SCHEMBL13846106 | 0.74 | LMNA (0.51) | ALDH1A1MAPTMEN1KMT2ARGS4 | |
| SCHEMBL29965354 | 0.73 | NPBWR1 (0.59) | PDE1APDE1BPDE1CALDH1A1MAPT | |
| SCHEMBL16544612 | 0.73 | DCTPP1 (0.56) | PDE1APDE1BPDE1CALDH1A1MAPT | |
| SCHEMBL23663174 | 0.72 | NPBWR1 (0.49) | PDE1APDE1BPDE1CALDH1A1MAPT | |
| SCHEMBL23671275 | 0.72 | NPBWR1 (0.49) | PDE1APDE1BPDE1CALDH1A1MAPT | |
| SCHEMBL13903082 | 0.72 | PPARA (0.67) | RGS4 | |
| SCHEMBL11075143 | 0.72 | L3MBTL1 (0.65) | ALDH1A1MAPTMEN1KMT2ADCTPP1 | |
| SCHEMBL25274507 | 0.72 | GAA (0.56) | ALDH1A1MAPTKDM4EALOX15CMA1 | |
| SCHEMBL19434434 | 0.71 | PDE1B (1.00) | PDE1APDE1BPDE1C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12454529-B2 | Piperazine cyclic ureas | Sironax Ltd. (KY) | 2025-10-28 | — | — | US | disclosed |
| CN-115697991-B | Piperazine cyclic ureas | 维泰瑞隆有限公司 | 2024-11-22 | — | — | CN | disclosed |
| US-20230203019-A1 | Piperazine Cyclic Ureas | SIRONAX (BEIJING) CO., LTD. (CN) | 2023-06-29 | — | — | US | disclosed |
| US-20230203019-A1 | Piperazine Cyclic Ureas | SIRONAX (BEIJING) CO., LTD. (CN) | 2023-06-29 | — | — | US | disclosed |
| US-20230203019-A1 | Piperazine Cyclic Ureas | SIRONAX (BEIJING) CO., LTD. (CN) | 2023-06-29 | — | — | US | disclosed |
| CN-115697991-A | Piperazine cyclic ureas | 维泰瑞隆有限公司 | 2023-02-03 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12454529-B2 | Piperazine cyclic ureas | RIPK1, RIPK3, RIPK4 | PDE1A 572/4885PDE1B 828/4885PDE1C 795/4885 |
| US-20230203019-A1 | Piperazine Cyclic Ureas | RIPK1, RIPK3, RIPK4 | PDE1A 572/4885PDE1B 828/4885PDE1C 795/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.