Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 2/20 | 0.36 |
| ▸ | CES1 | P23141 | 1/20 | 0.35 |
| ▸ | MLYCD | O95822 | 4/20 | 0.32 |
| ▸ | ACHE | P22303 | 2/20 | 0.32 |
| ▸ | PPIA | P62937 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30229135 | 0.75 | AR (0.35) | ARPPIAMEN1KMT2A | |
| SCHEMBL28999205 | 0.74 | CA12 (0.42) | MEN1MAPTKMT2A | |
| SCHEMBL25300766 | 0.73 | CCR2 (0.35) | CES1MLYCDACHE | |
| SCHEMBL30127875 | 0.69 | AR (0.34) | AR | |
| SCHEMBL16825502 | 0.68 | L3MBTL1 (0.40) | ARPPIAMEN1MAPTKMT2A | |
| SCHEMBL16825585 | 0.65 | AR (0.31) | AR | |
| SCHEMBL8848280 | 0.63 | CES1 (0.45) | CES1MLYCDACHE | |
| SCHEMBL8932128 | 0.63 | ACHE (0.42) | CES1MLYCDACHE | |
| SCHEMBL16825599 | 0.63 | — | — | |
| SCHEMBL7195729 | 0.62 | CES1 (0.54) | CES1MLYCDACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12565497-B2 | Sulfone derivatives | HOFFMANN-LA ROCHE INC. (US) | 2026-03-03 | — | — | US | disclosed |
| US-20230219953-A1 | SULFONE DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 2023-07-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230219953-A1 | SULFONE DERIVATIVES | SULT1E1, SULT1A1, SULT2A1 | AR 1892/4885CES1 966/4885MLYCD 4221/4885 |
| US-12565497-B2 | Sulfone derivatives | CXCR1, CCR1, SULT1E1 | AR 954/4885CES1 72/4885MLYCD 4646/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.