SCHEMBL25271016

SCHEMBL25271016

O=C1CNCCN1Cc1ccc(Br)cc1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.42
POLB P06746 1/20 0.42
L3MBTL1 Q9Y468 1/20 0.41
KDM4E B2RXH2 1/20 0.41
HSD11B1 P28845 1/20 0.40
CXCR4 P61073 2/20 0.40
SMN1; SMN2 Q16637 2/20 0.40
HDAC3 O15379 1/20 0.39
HDAC4 P56524 1/20 0.39
HDAC1 Q13547 1/20 0.39
HDAC7 Q8WUI4 1/20 0.39
HDAC2 Q92769 1/20 0.39
HDAC10 Q969S8 1/20 0.39
HDAC11 Q96DB2 1/20 0.39
HDAC8 Q9BY41 1/20 0.39
HDAC6 Q9UBN7 1/20 0.39
HDAC9 Q9UKV0 1/20 0.39
HDAC5 Q9UQL6 1/20 0.39
HRH3 Q9Y5N1 1/20 0.39
GRM2 Q14416 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4692001 0.85 MEN1 (0.47) ALDH1A1POLBL3MBTL1KDM4ECXCR4
SCHEMBL2899901 0.83 ALDH1A1 (0.63) ALDH1A1POLBL3MBTL1GRM2HTT
SCHEMBL14863940 0.83 HTR2C (0.43) ALDH1A1POLBL3MBTL1CXCR4SMN1; SMN2
SCHEMBL20129619 0.83 ALDH1A1 (0.42) ALDH1A1POLBL3MBTL1CXCR4SMN1; SMN2
SCHEMBL24648953 0.83 MGLL (0.43) ALDH1A1POLBL3MBTL1CXCR4SMN1; SMN2
SCHEMBL92331 0.83 L3MBTL1 (0.56) ALDH1A1POLBL3MBTL1HPGD
Hydrochloric Acid SCHEMBL4767938 0.82 ALDH1A1 (0.61) ALDH1A1POLBL3MBTL1GRM2HTT
SCHEMBL29452905 0.81 SMN1; SMN2 (0.49) POLBKDM4ESMN1; SMN2
Bromide SCHEMBL28426487 0.81 L3MBTL1 (0.54) ALDH1A1POLBL3MBTL1CXCR4HPGD
Hydrochloric Acid SCHEMBL4768580 0.81 L3MBTL1 (0.54) ALDH1A1POLBL3MBTL1HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023097187-A1 AMPK ACTIVATORS KALLYOPE, INC. (US) 2023-06-01 WO disclosed
WO-2023097187-A1 AMPK ACTIVATORS KALLYOPE, INC. (US) 2023-06-01 WO disclosed