Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAS2R14 | Q9NYV8 | 7/20 | 0.36 |
| ▸ | PTGES | O14684 | 2/20 | 0.35 |
| ▸ | APLNR | P35414 | 6/20 | 0.34 |
| ▸ | CXCR3 | P49682 | 3/20 | 0.34 |
| ▸ | TAS2R8 | Q9NYW2 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Potassium Ion SCHEMBL28474917 | 0.86 | APLNR (0.37) | TAS2R14PTGESAPLNRCXCR3 | |
| Potassium Ion SCHEMBL30725705 | 0.86 | APLNR (0.37) | TAS2R14PTGESAPLNRCXCR3 | |
| SCHEMBL30416047 | 0.85 | APLNR (0.36) | TAS2R14PTGESAPLNRCXCR3 | |
| SCHEMBL21392069 | 0.85 | APLNR (0.36) | TAS2R14PTGESAPLNRCXCR3 | |
| SCHEMBL22924965 | 0.80 | APLNR (0.38) | TAS2R14PTGESAPLNRCXCR3TAS2R8 | |
| SCHEMBL22924968 | 0.79 | APLNR (0.35) | TAS2R14PTGESAPLNRCNR2 | |
| SCHEMBL21392057 | 0.79 | APLNR (0.38) | TAS2R14PTGESAPLNRCXCR3 | |
| SCHEMBL30416333 | 0.79 | APLNR (0.38) | TAS2R14PTGESAPLNRCXCR3 | |
| SCHEMBL29228057 | 0.79 | APLNR (0.38) | TAS2R14PTGESAPLNRCXCR3TAS2R8 | |
| Potassium SCHEMBL30882859 | 0.79 | APLNR (0.38) | TAS2R14PTGESAPLNRCXCR3TAS2R8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230192673-A1 | Compounds | STEP PHARMA S.A.S. (FR) | 2023-06-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230192673-A1 | Compounds | CYP1A1, UGT1A1, CYP1A2 | TAS2R14 3350/4885PTGES 701/4885APLNR 3512/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.