Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APLNR | P35414 | 11/20 | 0.37 |
| ▸ | TAS2R14 | Q9NYV8 | 3/20 | 0.36 |
| ▸ | PTGES | O14684 | 1/20 | 0.36 |
| ▸ | MMP2 | P08253 | 3/20 | 0.35 |
| ▸ | MMP9 | P14780 | 3/20 | 0.35 |
| ▸ | MMP8 | P22894 | 3/20 | 0.35 |
| ▸ | MMP13 | P45452 | 3/20 | 0.35 |
| ▸ | CXCR3 | P49682 | 2/20 | 0.35 |
| ▸ | BMP1 | P13497 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Potassium Ion SCHEMBL28474917 | 1.00 | APLNR (0.37) | APLNRTAS2R14PTGESMMP2MMP9 | |
| SCHEMBL22924965 | 0.91 | APLNR (0.38) | APLNRTAS2R14PTGESMMP2MMP9 | |
| SCHEMBL21392057 | 0.90 | APLNR (0.38) | APLNRTAS2R14PTGESMMP2MMP9 | |
| SCHEMBL30416333 | 0.90 | APLNR (0.38) | APLNRTAS2R14PTGESMMP2MMP9 | |
| Potassium SCHEMBL30882859 | 0.90 | APLNR (0.38) | APLNRTAS2R14PTGESMMP2MMP9 | |
| SCHEMBL29228057 | 0.90 | APLNR (0.38) | APLNRTAS2R14PTGESMMP2MMP9 | |
| SCHEMBL22924968 | 0.86 | APLNR (0.35) | APLNRTAS2R14PTGESMMP2MMP9 | |
| Potassium Ion SCHEMBL25285698 | 0.86 | TAS2R14 (0.36) | APLNRTAS2R14PTGESCXCR3 | |
| SCHEMBL25778783 | 0.82 | APLNR (0.37) | APLNR | |
| SCHEMBL21392069 | 0.81 | APLNR (0.36) | APLNRTAS2R14PTGESCXCR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111868051-B | Aminopyrimidine derivatives as CTPS1 inhibitors | 斯泰普制药股份公司 | 2024-04-09 | — | — | CN | disclosed |
| EP-3768674-B1 | AMINOPYRIMIDINE DERIVATIVES AS CTPS1 INHIBITORS | STEP PHARMA S A S (FR) | 2024-01-03 | — | — | EP | disclosed |