Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.37 |
| ▸ | MAPT | P10636 | 7/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | CRHBP | P24387 | 1/20 | 0.37 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 3/20 | 0.36 |
| ▸ | GALR2 | O43603 | 1/20 | 0.36 |
| ▸ | MITF | O75030 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2533200 | 0.90 | ALDH1A1 (0.48) | ALDH1A1MAPTSMN1; SMN2GAAHPGD | |
| SCHEMBL2530387 | 0.89 | L3MBTL1 (0.40) | L3MBTL1ALDH1A1MAPTSMN1; SMN2MAPK1 | |
| SCHEMBL29434843 | 0.89 | L3MBTL1 (0.40) | L3MBTL1ALDH1A1MAPTSMN1; SMN2MAPK1 | |
| SCHEMBL2537785 | 0.84 | ITGA4 (0.36) | L3MBTL1ALDH1A1MAPTSMN1; SMN2MAPK1 | |
| SCHEMBL3393064 | 0.82 | L3MBTL1 (0.43) | L3MBTL1ALDH1A1MAPTSMN1; SMN2MAPK1 | |
| SCHEMBL2532268 | 0.78 | ALDH1A1 (0.49) | ALDH1A1MAPTSMN1; SMN2TDP1GAA | |
| SCHEMBL14334111 | 0.77 | PDK1 (0.43) | L3MBTL1ALDH1A1MAPTSMN1; SMN2MAPK1 | |
| SCHEMBL3385442 | 0.75 | ALDH1A1 (0.48) | L3MBTL1ALDH1A1MAPTSMN1; SMN2MAPK1 | |
| SCHEMBL8148188 | 0.73 | HPD (0.47) | L3MBTL1ALDH1A1MAPTSMN1; SMN2MAPK1 | |
| SCHEMBL21806057 | 0.73 | HPGD (0.34) | L3MBTL1ALDH1A1MAPTSMN1; SMN2MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8754240-B2 | Process for the manufacture of 4-fluoro-2-methyl-1H-indol-5-ol | ASTRAZENECA AB (SE) | 2014-06-17 | — | — | US | disclosed |
| EP-2540706-A2 | PROCESS FOR PREPARING INDOL-5-OXY-QUINAZOLINE DERIVATIVES AND INTERMEDIATES | AstraZeneca AB (Publ) (SE) | 2013-01-02 | — | — | EP | disclosed |
| EP-2540705-A2 | Process for preparing indol-5-oxy-quinazoline derivatives and intermediates | AstraZeneca AB (Publ) (SE) | 2013-01-02 | — | — | EP | disclosed |
| US-20110257395-A1 | Chemical Process | ASTRAZENECA AB (SE) | 2011-10-20 | — | — | US | disclosed |
| US-7851623-B2 | Chemical process | ASTRAZENECA AB (SE) | 2010-12-14 | — | — | US | disclosed |
| EP-2129657-A2 | PROCESS FOR PREPARING INDOL-5-OXY-QUINAZOLINE DERIVATIVES AND INTERMEDIATES | AstraZeneca AB (SE) | 2009-12-09 | — | — | EP | disclosed |
| US-20080221322-A1 | CHEMICAL PROCESS | ASTRAZENECA AB (SE) | 2008-09-11 | — | — | US | disclosed |
| WO-2008053221-A2 | PROCESS FOR PREPARING INDOL- 5 -OXY- QUINAZOLINE DERIVATIVES AND INTERMEDIATES | ASTRAZENECA AB (SE) | 2008-05-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110257395-A1 | Chemical Process | CYP3A5, CYP3A4, CYP3A7 | L3MBTL1 4673/4885ALDH1A1 609/4885MAPT 2718/4885 |
| US-20080221322-A1 | CHEMICAL PROCESS | CYP3A5, CYP3A4, CYP3A7 | L3MBTL1 4673/4885ALDH1A1 609/4885MAPT 2718/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.