Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.71 |
| ▸ | MAPT | P10636 | 4/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.71 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.68 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.64 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.57 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.57 |
| ▸ | POLB | P06746 | 3/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
| ▸ | BLM | P54132 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1760833 | 1.00 | KDM4E (0.71) | KDM4EMAPTALDH1A1HSD17B10ALOX15 | |
| SCHEMBL1760831 | 1.00 | KDM4E (0.71) | KDM4EMAPTALDH1A1HSD17B10ALOX15 | |
| SCHEMBL16084531 | 0.87 | KDM4E (0.84) | KDM4EMAPTALDH1A1HSD17B10ALOX15 | |
| SCHEMBL3830104 | 0.83 | ALDH1A1 (0.58) | KDM4EMAPTALDH1A1HSD17B10ALOX15 | |
| SCHEMBL3830107 | 0.83 | ALDH1A1 (0.58) | KDM4EMAPTALDH1A1HSD17B10ALOX15 | |
| SCHEMBL8870328 | 0.83 | ALDH1A1 (0.58) | KDM4EMAPTALDH1A1HSD17B10ALOX15 | |
| SCHEMBL4743901 | 0.83 | KDM4E (1.00) | KDM4EMAPTALDH1A1HSD17B10ALOX15 | |
| SCHEMBL11067751 | 0.83 | KDM4E (1.00) | KDM4EMAPTALDH1A1HSD17B10ALOX15 | |
| SCHEMBL4743903 | 0.83 | KDM4E (1.00) | KDM4EMAPTALDH1A1HSD17B10ALOX15 | |
| SCHEMBL3826154 | 0.83 | ALDH1A1 (1.00) | KDM4EMAPTALDH1A1HSD17B10ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019243576-A1 | GLUCOSE-SENSITIVE PEPTIDE HORMONES | GUBRA APS (DK) | 2019-12-26 | — | — | WO | disclosed |
| WO-2019243576-A1 | GLUCOSE-SENSITIVE PEPTIDE HORMONES | GUBRA APS (DK) | 2019-12-26 | — | — | WO | disclosed |
| US-20120083599-A1 | Biomolecular Labelling Using Multifunctional Biotin Analogues | UNIVERSITY OF NOTTINGHAM (GB) | 2012-04-05 | — | — | US | disclosed |
| US-8039465-B2 | Cytoskeletal active compounds, composition and use | INSPIRE PHARMACEUTICALS, INC. (US) | 2011-10-18 | — | — | US | disclosed |
| US-8039465-B2 | Cytoskeletal active compounds, composition and use | INSPIRE PHARMACEUTICALS, INC. (US) | 2011-10-18 | — | — | US | disclosed |
| US-7947850-B2 | Process for the preparation of 3,4-disubstituted-thiazolidin-2-ones | INSPIRE PHARMACEUTICALS, INC. (US) | 2011-05-24 | — | — | US | disclosed |
| US-20100130572-A1 | CYTOSKELETAL ACTIVE COMPOUNDS, COMPOSITION AND USE | LAMPE JOHN W | 2010-05-27 | — | — | US | disclosed |
| US-20100130572-A1 | CYTOSKELETAL ACTIVE COMPOUNDS, COMPOSITION AND USE | LAMPE JOHN W | 2010-05-27 | — | — | US | disclosed |
| US-7666861-B2 | Cytoskeletal active compounds, composition and use | INSPIRE PHARMACEUTICALS, INC. (US) | 2010-02-23 | — | — | US | disclosed |
| US-7666861-B2 | Cytoskeletal active compounds, composition and use | INSPIRE PHARMACEUTICALS, INC. (US) | 2010-02-23 | — | — | US | disclosed |
| US-20080076735-A1 | CYTOSKELETAL ACTIVE COMPOUNDS, COMPOSITION AND USE | CHATTEM INC. | 2008-03-27 | — | — | US | disclosed |
| US-7320974-B2 | Cytoskeletal active compounds, compositions and use | INSPIRE PHARMACEUTICALS, INC. (US) | 2008-01-22 | — | — | US | disclosed |
| US-7320974-B2 | Cytoskeletal active compounds, compositions and use | INSPIRE PHARMACEUTICALS, INC. (US) | 2008-01-22 | — | — | US | disclosed |
| EP-1866316-A2 | CYTOSKELETAL ACTIVE COMPOUNDS, COMPOSITION AND USE | Inspire Pharmaceuticals, Inc. (US) | 2007-12-19 | — | — | EP | disclosed |
| US-20070225504-A1 | PROCESS FOR THE PREPARATION OF 3,4-DISUBSTITUTED-THIAZOLIDIN-2-ONES | INSPIRE PHARMACEUTICALS, INC. | 2007-09-27 | — | — | US | disclosed |
| WO-2007109786-A2 | PROCESS FOR THE PREPARATION OF 3,4-DISUBSTITUTED-THIAZOLIDIN-2-ONES | INSPIRE PHARMACEUTICALS, INC. (US) | 2007-09-27 | — | — | WO | disclosed |
| WO-2006104897-A2 | CYTOSKELETAL ACTIVE COMPOUNDS, COMPOSITION AND USE | INSPIRE PHARMACEUTICALS, INC. (US) | 2006-10-05 | — | — | WO | disclosed |
| US-20060217427-A1 | Cytoskeletal active compounds, compositions and use | INSPIRE PHARMACEUTICALS, INC. | 2006-09-28 | — | — | US | disclosed |
| US-4410542-A | HYPOTENSIVE AGENTS, PYRROLINE-1,2-DICARBOXYLIC ACID DERIVATIVES | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1983-10-18 | — | — | US | disclosed |
| US-4347371-A | HYPERTENSIVE AGENTS; ANTIDIABETIC AGENTS; VISION DEFECTS | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1982-08-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070225504-A1 | PROCESS FOR THE PREPARATION OF 3,4-DISUBSTITUTED-THIAZOLIDIN-2-ONES | ACTR2, ACTR5, ACTR3 | KDM4E 4301/4885MAPT 171/4885ALDH1A1 4259/4885 |
| US-20060217427-A1 | Cytoskeletal active compounds, compositions and use | RHOA, ACTB, ROCK1 | KDM4E 3238/4885MAPT 45/4885ALDH1A1 4237/4885 |
| US-20120083599-A1 | Biomolecular Labelling Using Multifunctional Biotin Analogues | BTD, URB2, RAET1L | KDM4E 2501/4885MAPT 1902/4885ALDH1A1 260/4885 |
| US-20100130572-A1 | CYTOSKELETAL ACTIVE COMPOUNDS, COMPOSITION AND USE | RHOA, ACTB, ROCK1 | KDM4E 3389/4885MAPT 39/4885ALDH1A1 4181/4885 |
| US-20080076735-A1 | CYTOSKELETAL ACTIVE COMPOUNDS, COMPOSITION AND USE | RHOA, ACTB, ROCK1 | KDM4E 3389/4885MAPT 39/4885ALDH1A1 4181/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.