Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.71 |
| ▸ | MAPT | P10636 | 4/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.71 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.68 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.64 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.57 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.57 |
| ▸ | POLB | P06746 | 3/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
| ▸ | BLM | P54132 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1760831 | 1.00 | KDM4E (0.71) | KDM4EMAPTALDH1A1HSD17B10ALOX15 | |
| SCHEMBL2533522 | 1.00 | KDM4E (0.71) | KDM4EMAPTALDH1A1HSD17B10ALOX15 | |
| SCHEMBL16084531 | 0.87 | KDM4E (0.84) | KDM4EMAPTALDH1A1HSD17B10ALOX15 | |
| SCHEMBL3830104 | 0.83 | ALDH1A1 (0.58) | KDM4EMAPTALDH1A1HSD17B10ALOX15 | |
| SCHEMBL3830107 | 0.83 | ALDH1A1 (0.58) | KDM4EMAPTALDH1A1HSD17B10ALOX15 | |
| SCHEMBL8870328 | 0.83 | ALDH1A1 (0.58) | KDM4EMAPTALDH1A1HSD17B10ALOX15 | |
| SCHEMBL4743901 | 0.83 | KDM4E (1.00) | KDM4EMAPTALDH1A1HSD17B10ALOX15 | |
| SCHEMBL11067751 | 0.83 | KDM4E (1.00) | KDM4EMAPTALDH1A1HSD17B10ALOX15 | |
| SCHEMBL4743903 | 0.83 | KDM4E (1.00) | KDM4EMAPTALDH1A1HSD17B10ALOX15 | |
| SCHEMBL3826154 | 0.83 | ALDH1A1 (1.00) | KDM4EMAPTALDH1A1HSD17B10ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7947850-B2 | Process for the preparation of 3,4-disubstituted-thiazolidin-2-ones | INSPIRE PHARMACEUTICALS, INC. (US) | 2011-05-24 | — | — | US | disclosed |
| EP-2099778-A2 | AMIDO ANTI-VIRAL COMPOUNDS | Smithkline Beecham Corporation (US) | 2009-09-16 | — | — | EP | disclosed |
| EP-1996192-A2 | PROCESS FOR THE PREPARATION OF 3,4-DISUBSTITUTED-THIAZOLIDIN-2-ONES | Inspire Pharmaceuticals, Inc. (US) | 2008-12-03 | — | — | EP | disclosed |
| US-20080287683-A1 | PROCESS FOR THE PREPARATION OF 3,4-DISUBSTITUTED-THIAZOLIDIN-2-ONES | DECAMP JONATHAN B | 2008-11-20 | — | — | US | disclosed |
| WO-2008117982-A1 | HETEROCYCLIC CARBOXYLIC ACID DERIVATIVES AND PHARMACEUTICAL COMPOSITION FOR INHIBITING LIPID ACCUMULATION CONTAINING SAME | CRYSTAL GENOMICS, INC. (KR) | 2008-10-02 | — | — | WO | disclosed |
| US-7414137-B2 | Process for the preparation of 3,4-disubstituted-thiazolidin-2-ones | INSPIRE PHARMACEUTICALS, INC. (US) | 2008-08-19 | — | — | US | disclosed |
| US-20080181866-A1 | Amido Anti-viral Compounds | GENELABS TECHNOLOGIES, INC. | 2008-07-31 | — | — | US | disclosed |
| WO-2008064218-A2 | AMIDO ANTI-VIRAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-05-29 | — | — | WO | disclosed |
| WO-2007109786-A2 | PROCESS FOR THE PREPARATION OF 3,4-DISUBSTITUTED-THIAZOLIDIN-2-ONES | INSPIRE PHARMACEUTICALS, INC. (US) | 2007-09-27 | — | — | WO | disclosed |
| US-20070225504-A1 | PROCESS FOR THE PREPARATION OF 3,4-DISUBSTITUTED-THIAZOLIDIN-2-ONES | INSPIRE PHARMACEUTICALS, INC. | 2007-09-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070225504-A1 | PROCESS FOR THE PREPARATION OF 3,4-DISUBSTITUTED-THIAZOLIDIN-2-ONES | ACTR2, ACTR5, ACTR3 | KDM4E 4301/4885MAPT 171/4885ALDH1A1 4259/4885 |
| US-20080181866-A1 | Amido Anti-viral Compounds | ZC3HAV1, U2SURP, ZC3HAV1L | KDM4E 2989/4885MAPT 52/4885ALDH1A1 4630/4885 |
| US-20080287683-A1 | PROCESS FOR THE PREPARATION OF 3,4-DISUBSTITUTED-THIAZOLIDIN-2-ONES | ACTR2, ACTR5, ACTR3 | KDM4E 4301/4885MAPT 171/4885ALDH1A1 4259/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.