SCHEMBL25344822

SCHEMBL25344822

Fc1ccc2[nH]cc(C3CCN(CCCCl)CC3)c2c1

nearest known ligand 0.80

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
HTR1A P08908 7/20 0.66
SLC6A4 P31645 6/20 0.66
HTR7 P34969 5/20 0.66
DRD2 P14416 5/20 0.66
HTR2A P28223 3/20 0.66
HTR6 P50406 3/20 0.66
ADRA1D P25100 2/20 0.66
OPRM1 P35372 2/20 0.66
OPRK1 P41145 2/20 0.66
OPRL1 P41146 2/20 0.66
HTR1D P28221 4/20 0.60
HTR1B P28222 3/20 0.59
CHRM2 P08172 1/20 0.59

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL7255624 0.88 ADRA1D (0.83) HTR1ASLC6A4HTR7DRD2HTR2A
SCHEMBL8557344 0.87 HTR1A (0.76) HTR1ASLC6A4HTR7DRD2HTR2A
SCHEMBL8877428 0.86 OPRM1 (0.67) HTR1ASLC6A4HTR7DRD2HTR2A
SCHEMBL8557097 0.86 HTR1A (0.70) HTR1ASLC6A4HTR7DRD2HTR2A
SCHEMBL5389005 0.85 HTR1D (0.63) HTR1ASLC6A4HTR7DRD2HTR2A
SCHEMBL8557700 0.84 MPO (0.71) HTR1ASLC6A4HTR7DRD2HTR2A
SCHEMBL5385305 0.84 DRD2 (0.65) HTR1ASLC6A4HTR7DRD2HTR2A
SCHEMBL11039326 0.84 ADRA1D (0.77) SLC6A4ADRA1D
SCHEMBL5389529 0.83 HTR1D (0.66) HTR1ASLC6A4HTR7DRD2HTR2A
SCHEMBL5380987 0.82 OPRM1 (0.62) HTR1ASLC6A4HTR7DRD2HTR2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4463455-B1 HETEROALICYCLIC DERIVATIVES AND THEIR USE IN THE TREATMENT OF CNS DISORDERS SUVEN LIFE SCIENCES LTD (IN) 2026-04-29 EP disclosed
US-12391698-B2 Substituted piperidines and piperazines and methods for the treatment of CNS disorders SUVEN LIFE SCIENCES LIMITED (IN) 2025-08-19 US disclosed
US-20250092049-A1 HETEROALICYCLIC DERIVATIVES AND THEIR USE IN THE TREATMENT OF CNS DISORDERS SUVEN LIFE SCIENCES LIMITED (IN) 2025-03-20 US disclosed
EP-4463455-A1 HETEROALICYCLIC DERIVATIVES AND THEIR USE IN THE TREATMENT OF CNS DISORDERS Suven Life Sciences Limited (IN) 2024-11-20 EP disclosed
WO-2023135528-A1 HETEROALICYCLIC DERIVATIVES AND THEIR USE IN THE TREATMENT OF CNS DISORDERS SUVEN LIFE SCIENCES LIMITED (IN) 2023-07-20 WO disclosed
WO-2023135528-A1 HETEROALICYCLIC DERIVATIVES AND THEIR USE IN THE TREATMENT OF CNS DISORDERS SUVEN LIFE SCIENCES LIMITED (IN) 2023-07-20 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12391698-B2 Substituted piperidines and piperazines and methods for the treatment of CNS disorders GRIN2C, SLC1A2, CNR2 HTR1A 127/4885SLC6A4 60/4885HTR7 245/4885
US-20250092049-A1 HETEROALICYCLIC DERIVATIVES AND THEIR USE IN THE TREATMENT OF CNS DISORDERS GRIN2C, CNR2, INA HTR1A 183/4885SLC6A4 63/4885HTR7 259/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.