Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F7 | P08709 | 1/20 | 0.73 |
| ▸ | F3 | P13726 | 1/20 | 0.73 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.63 |
| ▸ | GABRP | O00591 | 4/20 | 0.58 |
| ▸ | GABRD | O14764 | 4/20 | 0.58 |
| ▸ | GABRA1 | P14867 | 4/20 | 0.58 |
| ▸ | GABRB1 | P18505 | 4/20 | 0.58 |
| ▸ | GABRG2 | P18507 | 4/20 | 0.58 |
| ▸ | GABRB3 | P28472 | 4/20 | 0.58 |
| ▸ | GABRA5 | P31644 | 4/20 | 0.58 |
| ▸ | GABRA3 | P34903 | 4/20 | 0.58 |
| ▸ | GABRA2 | P47869 | 4/20 | 0.58 |
| ▸ | GABRB2 | P47870 | 4/20 | 0.58 |
| ▸ | GABRA4 | P48169 | 4/20 | 0.58 |
| ▸ | GABRE | P78334 | 4/20 | 0.58 |
| ▸ | GABRA6 | Q16445 | 4/20 | 0.58 |
| ▸ | GABRG1 | Q8N1C3 | 4/20 | 0.58 |
| ▸ | GABRG3 | Q99928 | 4/20 | 0.58 |
| ▸ | GABRQ | Q9UN88 | 4/20 | 0.58 |
| ▸ | CDK4 | P11802 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7538181 | 0.87 | NR4A2 (0.63) | F7F3NR4A2GABRPGABRD | |
| SCHEMBL592274 | 0.86 | F7 (0.77) | F7F3NR4A2GABRPGABRD | |
| SCHEMBL2535534 | 0.85 | F7 (0.71) | F7F3NR4A2GABRPGABRD | |
| SCHEMBL1434913 | 0.84 | F7 (1.00) | F7F3NR4A2GABRPGABRD | |
| SCHEMBL14631301 | 0.82 | F7 (0.49) | F7F3NR4A2GABRPGABRD | |
| SCHEMBL7533649 | 0.82 | KDM4E (0.59) | F7F3CDK4CCND1 | |
| SCHEMBL7287695 | 0.82 | LMNA (0.68) | F7F3NR4A2CDK4CCND1 | |
| SCHEMBL1558405 | 0.82 | NR4A2 (0.61) | F7F3NR4A2GABRA1GABRB1 | |
| SCHEMBL28369562 | 0.81 | F7 (0.65) | F7F3NR4A2GABRPGABRD | |
| SCHEMBL13013297 | 0.81 | NR4A2 (0.74) | F7F3NR4A2GABRPGABRD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113480524-A | Alkaloid hamacanthins series derivatives, and preparation method and application thereof | 河北工业大学 | 2021-10-08 | — | — | CN | disclosed |
| CN-107149602-B | Application of indole compounds and derivatives thereof in preparation of anti-HIV drugs | 中国医学科学院药物研究所 | 2020-10-09 | — | — | CN | disclosed |
| CN-107149603-B | Application of indole compounds and derivatives thereof in preparation of anti-influenza virus drugs | 中国医学科学院药物研究所 | 2020-07-14 | — | — | CN | disclosed |
| CN-107176921-B | Indole compounds with antiviral activity in isatis root and derivatives thereof | 中国医学科学院药物研究所 | 2020-03-31 | — | — | CN | disclosed |
| US-9321722-B2 | Bis-indolic derivatives, their uses in particular as antibacterials | UNIVERSITE JOSEPH FOURIER (FR) | 2016-04-26 | — | — | US | disclosed |
| EP-1859798-B1 | N-(2-ARYLETHYL) BENZYLAMINES AS ANTAGONISTS OF THE 5-HT6 RECEPTOR | LILLY CO ELI (US) | 2015-12-30 | — | — | EP | disclosed |
| US-20140228359-A1 | BIS-INDOLIC DERIVATIVES, THEIR USES IN PARTICULAR AS ANTIBACTERIALS | UNIVERSITE JOSEPH FOURIER (FR) | 2014-08-14 | — | — | US | disclosed |
| EP-2548865-B1 | Novel bis-indolic derivatives, their uses in particular as antibacterials | UNIV JOSEPH FOURIER (FR) | 2014-03-05 | — | — | EP | disclosed |
| EP-2548865-A1 | Novel bis-indolic derivatives, their uses in particular as antibacterials | Université Joseph Fourier (FR) | 2013-01-23 | — | — | EP | disclosed |
| US-8044090-B2 | N-(2-arylethyl)benzylamines as antagonists of the 5-HT6 receptor | ELI LILLY (US) | 2011-10-25 | — | — | US | disclosed |
| EP-1379239-A2 | N-(2-ARYLETHYL) BENZYLAMINES AS ANTAGONISTS OF THE 5-HT6 RECEPTOR | ELI LILLY AND COMPANY (US) | 2004-01-14 | — | — | EP | disclosed |
| EP-1007523-B1 | INDOLE AND 2,3-DIHYDROINDOLE DERIVATIVES, THEIR PREPARATION AND USE | LUNDBECK & CO AS H (DK) | 2003-10-22 | — | — | EP | disclosed |
| US-20030018050-A1 | Indole and 2,3-dihydroindole derivatives, their preparation and use | H. LUNDBECK A/S (DK) | 2003-01-23 | — | — | US | disclosed |
| US-6476035-B1 | Indole and 2,3-dihydroindole derivatives, their preparation and use | H. LUNDBECK A/S (DK) | 2002-11-05 | — | — | US | disclosed |
| WO-2002078693-A2 | N-(2-ARYLETHYL)BENZYLAMINES AS ANTAGONISTS OF THE 5-HT6 RECEPTOR | ELI LILLY AND COMPANY (US) | 2002-10-10 | — | — | WO | disclosed |
| EP-1007523-A1 | INDOLE AND 2,3-DIHYDROINDOLE DERIVATIVES, THEIR PREPARATION AND USE | H. LUNDBECK A/S (DK) | 2000-06-14 | — | — | EP | disclosed |
| WO-1999005140-A1 | INDOLE AND 2,3-DIHYDROINDOLE DERIVATIVES, THEIR PREPARATION AND USE | H. LUNDBECK A/S (DK) | 1999-02-04 | — | — | WO | disclosed |
| US-5192770-A | Antiemetic, anxiolytic, cognition activator | SYNTEX (U.S.A.) INC. (US) | 1993-03-09 | — | — | US | disclosed |
| EP-0490263-A1 | Alpha-oxoacetamide derivatives | SYNTEX (U.S.A.) INC. (US) | 1992-06-17 | — | — | EP | disclosed |
| US-RE28973-E | PARKINSON'S DISEASE | A. H. ROBINS COMPANY, INCORPORATED (US) | 1976-09-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030018050-A1 | Indole and 2,3-dihydroindole derivatives, their preparation and use | TPH1, HTR1A, HTR3A | F7 2432/4885F3 1663/4885NR4A2 1366/4885 |
| US-20140228359-A1 | BIS-INDOLIC DERIVATIVES, THEIR USES IN PARTICULAR AS ANTIBACTERIALS | IDO1, IDO2, AANAT | F7 4536/4885F3 4165/4885NR4A2 3867/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.