Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A2 | P43354 | 2/20 | 0.63 |
| ▸ | F7 | P08709 | 1/20 | 0.54 |
| ▸ | F3 | P13726 | 1/20 | 0.54 |
| ▸ | AVPR1A | P37288 | 2/20 | 0.49 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.49 |
| ▸ | GABRP | O00591 | 5/20 | 0.48 |
| ▸ | GABRD | O14764 | 5/20 | 0.48 |
| ▸ | GABRA1 | P14867 | 5/20 | 0.48 |
| ▸ | GABRB1 | P18505 | 5/20 | 0.48 |
| ▸ | GABRG2 | P18507 | 5/20 | 0.48 |
| ▸ | GABRB3 | P28472 | 5/20 | 0.48 |
| ▸ | GABRA5 | P31644 | 5/20 | 0.48 |
| ▸ | GABRA3 | P34903 | 5/20 | 0.48 |
| ▸ | GABRA2 | P47869 | 5/20 | 0.48 |
| ▸ | GABRB2 | P47870 | 5/20 | 0.48 |
| ▸ | GABRA4 | P48169 | 5/20 | 0.48 |
| ▸ | GABRE | P78334 | 5/20 | 0.48 |
| ▸ | GABRA6 | Q16445 | 5/20 | 0.48 |
| ▸ | GABRG1 | Q8N1C3 | 5/20 | 0.48 |
| ▸ | GABRG3 | Q99928 | 5/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL840574 | 0.87 | NR4A2 (0.63) | NR4A2F7F3AVPR1AGPR84 | |
| SCHEMBL2535532 | 0.87 | F7 (0.73) | NR4A2F7F3GABRPGABRD | |
| SCHEMBL3716737 | 0.85 | NR4A2 (0.61) | NR4A2F7F3AVPR1AGPR84 | |
| SCHEMBL30392504 | 0.84 | F7 (0.74) | NR4A2F7F3AVPR1AGPR84 | |
| SCHEMBL613332 | 0.84 | F7 (0.74) | NR4A2F7F3AVPR1AGPR84 | |
| SCHEMBL17495632 | 0.84 | NR4A2 (0.60) | NR4A2F7F3AVPR1AGPR84 | |
| Ammonia Solution, Strong SCHEMBL4556453 | 0.83 | F7 (0.72) | NR4A2F7F3AVPR1AGPR84 | |
| SCHEMBL23551182 | 0.82 | NR4A2 (0.63) | NR4A2ALDH1A1MEN1KMT2A | |
| SCHEMBL14631708 | 0.82 | CYP2A6 (0.49) | NR4A2 | |
| SCHEMBL3124053 | 0.82 | TDO2 (0.50) | NR4A2GPR84GABRPGABRDGABRA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9321722-B2 | Bis-indolic derivatives, their uses in particular as antibacterials | UNIVERSITE JOSEPH FOURIER (FR) | 2016-04-26 | — | — | US | disclosed |
| US-20140228359-A1 | BIS-INDOLIC DERIVATIVES, THEIR USES IN PARTICULAR AS ANTIBACTERIALS | UNIVERSITE JOSEPH FOURIER (FR) | 2014-08-14 | — | — | US | disclosed |
| EP-2548865-B1 | Novel bis-indolic derivatives, their uses in particular as antibacterials | UNIV JOSEPH FOURIER (FR) | 2014-03-05 | — | — | EP | disclosed |
| EP-2548865-A1 | Novel bis-indolic derivatives, their uses in particular as antibacterials | Université Joseph Fourier (FR) | 2013-01-23 | — | — | EP | disclosed |
| US-20020128272-A1 | 4,5,6, and 7-indole and indoline derivatives, their preparation and use | H. LUNDBECK A/S (DK) | 2002-09-12 | — | — | US | disclosed |
| US-6391882-B1 | PSYCHOLOGICAL DISORDERS; ANTIDEPRESSANTS | H. LUNDBECK A/S (DK) | 2002-05-21 | — | — | US | disclosed |
| EP-1089997-A1 | 4,5,6 AND 7-INDOLE AND INDOLINE DERIVATIVES, THEIR PREPARATION AND USE | H.Lundbeck A/S (DK) | 2001-04-11 | — | — | EP | disclosed |
| WO-1999067237-A1 | 4,5,6 AND 7-INDOLE AND INDOLINE DERIVATIVES, THEIR PREPARATION AND USE | H. LUNDBECK A/S (DK) | 1999-12-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020128272-A1 | 4,5,6, and 7-indole and indoline derivatives, their preparation and use | HTR2C, HTR1A, HTR7 | NR4A2 668/4885F7 399/4885F3 3231/4885 |
| US-20140228359-A1 | BIS-INDOLIC DERIVATIVES, THEIR USES IN PARTICULAR AS ANTIBACTERIALS | IDO1, IDO2, AANAT | NR4A2 3867/4885F7 4536/4885F3 4165/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.