Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK1 | P51617 | 1/20 | 0.45 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.45 |
| ▸ | KDR | P35968 | 7/20 | 0.45 |
| ▸ | FLT4 | P35916 | 5/20 | 0.45 |
| ▸ | FLT1 | P17948 | 1/20 | 0.45 |
| ▸ | EGFR | P00533 | 3/20 | 0.44 |
| ▸ | CSF1R | P07333 | 4/20 | 0.44 |
| ▸ | PDGFRB | P09619 | 4/20 | 0.44 |
| ▸ | FLT3 | P36888 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.43 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.42 |
| ▸ | BRAF | P15056 | 1/20 | 0.42 |
| ▸ | RET | P07949 | 1/20 | 0.41 |
| ▸ | KIF5B | P33176 | 1/20 | 0.41 |
| ▸ | KIT | P10721 | 1/20 | 0.41 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.41 |
| ▸ | MET | P08581 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1549776 | 0.89 | MET (0.48) | KDRMEN1ALDH1A1KMT2AKIT | |
| SCHEMBL297890 | 0.81 | CTSV (0.47) | MEN1ALDH1A1KMT2A | |
| SCHEMBL28343434 | 0.79 | TRPA1 (0.56) | IRAK1IRAK4KDRFLT4FLT1 | |
| SCHEMBL1549363 | 0.76 | MET (0.43) | KDRPDGFRAMET | |
| SCHEMBL10296341 | 0.76 | MET (0.42) | KDRFLT4EGFRCSF1RPDGFRB | |
| SCHEMBL28512289 | 0.75 | MET (0.47) | KDRPDGFRBPDGFRAMET | |
| SCHEMBL6788900 | 0.75 | IRAK1 (0.59) | IRAK1IRAK4KDRFLT4FLT1 | |
| SCHEMBL20911302 | 0.74 | CSF1R (0.56) | IRAK1IRAK4KDRFLT4EGFR | |
| SCHEMBL20897394 | 0.74 | FLT4 (0.56) | IRAK1IRAK4KDRFLT4FLT1 | |
| SCHEMBL28907136 | 0.74 | MET (0.48) | KDRPDGFRAMET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8754240-B2 | Process for the manufacture of 4-fluoro-2-methyl-1H-indol-5-ol | ASTRAZENECA AB (SE) | 2014-06-17 | — | — | US | disclosed |
| EP-2540706-A2 | PROCESS FOR PREPARING INDOL-5-OXY-QUINAZOLINE DERIVATIVES AND INTERMEDIATES | AstraZeneca AB (Publ) (SE) | 2013-01-02 | — | — | EP | disclosed |
| EP-2540705-A2 | Process for preparing indol-5-oxy-quinazoline derivatives and intermediates | AstraZeneca AB (Publ) (SE) | 2013-01-02 | — | — | EP | disclosed |
| US-20110257395-A1 | Chemical Process | ASTRAZENECA AB (SE) | 2011-10-20 | — | — | US | disclosed |
| US-7851623-B2 | Chemical process | ASTRAZENECA AB (SE) | 2010-12-14 | — | — | US | disclosed |
| EP-2129657-A2 | PROCESS FOR PREPARING INDOL-5-OXY-QUINAZOLINE DERIVATIVES AND INTERMEDIATES | AstraZeneca AB (SE) | 2009-12-09 | — | — | EP | disclosed |
| US-20080221322-A1 | CHEMICAL PROCESS | ASTRAZENECA AB (SE) | 2008-09-11 | — | — | US | disclosed |
| WO-2008053221-A2 | PROCESS FOR PREPARING INDOL- 5 -OXY- QUINAZOLINE DERIVATIVES AND INTERMEDIATES | ASTRAZENECA AB (SE) | 2008-05-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110257395-A1 | Chemical Process | CYP3A5, CYP3A4, CYP3A7 | IRAK1 3540/4885IRAK4 2760/4885KDR 3684/4885 |
| US-20080221322-A1 | CHEMICAL PROCESS | CYP3A5, CYP3A4, CYP3A7 | IRAK1 3540/4885IRAK4 2760/4885KDR 3684/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.