SCHEMBL2536617

SCHEMBL2536617

Nc1cc(F)c(F)cc1Br

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.41
MAPT P10636 2/20 0.41
POLB P06746 2/20 0.41
L3MBTL1 Q9Y468 2/20 0.41
MEN1 O00255 1/20 0.41
APAF1 O14727 1/20 0.41
THRB P10828 1/20 0.41
NR4A1 P22736 1/20 0.41
RECQL P46063 1/20 0.41
BLM P54132 1/20 0.41
KMT2A Q03164 1/20 0.41
PTPN11 Q06124 1/20 0.41
NPSR1 Q6W5P4 1/20 0.41
CA1 P00915 3/20 0.37
CA2 P00918 3/20 0.37
CA9 Q16790 3/20 0.37
KDM1A O60341 4/20 0.35
KCNH2 Q12809 4/20 0.35
KDM1B Q8NB78 2/20 0.35
GAA P10253 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6659815 0.86 ALDH1A1 (0.40) ALDH1A1MAPTPOLBL3MBTL1MEN1
SCHEMBL350192 0.86 ALDH1A1 (0.40) ALDH1A1MAPTPOLBL3MBTL1MEN1
SCHEMBL21597029 0.86 KDM1A (0.43) ALDH1A1MAPTPOLBL3MBTL1MEN1
SCHEMBL23885388 0.86 ALDH1A1 (0.40) ALDH1A1MAPTPOLBL3MBTL1MEN1
SCHEMBL30053965 0.86 ALDH1A1 (0.40) ALDH1A1MAPTPOLBL3MBTL1MEN1
SCHEMBL29365100 0.80 ALDH1A1 (0.46) ALDH1A1MAPTPOLBL3MBTL1KMT2A
SCHEMBL275963 0.80 ALDH1A1 (0.46) ALDH1A1MAPTPOLBL3MBTL1KMT2A
SCHEMBL21834387 0.79 ALDH1A1 (0.35) ALDH1A1MAPTPOLBL3MBTL1MEN1
SCHEMBL3168767 0.79 GAA (0.43) ALDH1A1MAPTPOLBL3MBTL1MEN1
SCHEMBL15515282 0.79 CYP3A4 (0.46) ALDH1A1MAPTPOLBL3MBTL1MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 102 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12509431-B2 1,4-dihydroquinazolinone compounds and uses thereof EDGEWISE THERAPEUTICS, INC. (US) 2025-12-30 US disclosed
US-20250361213-A1 1,4-DIHYDROQUINAZOLINONE COMPOUNDS AND USES THEREOF EDGEWISE THERAPEUTICS INC (US) 2025-11-27 US disclosed
WO-2025235686-A1 FLUOROCAMPTOTHECIN COMPOUNDS, CONJUGATES, AND METHODS THEREOF Aarvik Therapeutics, Inc. (US) 2025-11-13 WO disclosed
EP-4594307-A1 1,4-DIHYDROQUINAZOLINONE COMPOUNDS AND USES THEREOF EDGEWISE THERAPEUTICS, INC. (US) 2025-08-06 EP disclosed
US-20250171431-A1 HETEROCYCLIC INHIBITORS OF IGF-1R FOR TREATMENT OF DISEASE HORIZON THERAPEUTICS IRELAND DAC (IE) 2025-05-29 US disclosed
US-20250154111-A1 1,4-DIHYDROQUINAZOLINONE COMPOUNDS AND USES THEREOF EDGEWISE THERAPEUTICS, INC. 2025-05-15 US disclosed
WO-2025030163-A1 HETEROCYCLIC INHIBITORS OF IGF-1R FOR TREATMENT OF DISEASE HORIZON THERAPEUTICS IRELAND DAC (IE) 2025-02-06 WO disclosed
US-20240376120-A1 CAMPTOTHECIN COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF SHANGHAI BEST-LINK BIOSCIENCE, LLC (CN) 2024-11-14 US disclosed
CN-117940432-A Camptothecins compound, preparation method and application thereof 上海弼领生物技术有限公司 2024-04-26 CN disclosed
WO-2024073426-A1 1,4-DIHYDROQUINAZOLINONE COMPOUNDS AND USES THEREOF EDGEWISE THERAPEUTICS, INC. (US) 2024-04-04 WO disclosed
EP-1379239-A2 N-(2-ARYLETHYL) BENZYLAMINES AS ANTAGONISTS OF THE 5-HT6 RECEPTOR ELI LILLY AND COMPANY (US) 2004-01-14 EP disclosed
WO-2002078693-A2 N-(2-ARYLETHYL)BENZYLAMINES AS ANTAGONISTS OF THE 5-HT6 RECEPTOR ELI LILLY AND COMPANY (US) 2002-10-10 WO disclosed
EP-1204650-A1 SUBSTITUTED 2-ARYLBENZAZOLE COMPOUNDS AND THEIR USE AS ANTITUMOUR AGENTS Cancer Research Ventures Limited (GB) 2002-05-15 EP disclosed
EP-1202965-A1 INDOLE DERIVATIVES, PROCESSES FOR THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR MEDICINAL APPLICATION VERNALIS RESEARCH LIMITED (GB) 2002-05-08 EP disclosed
WO-2001014354-A1 SUBSTITUTED 2-ARYLBENZAZOLE COMPOUNDS AND THEIR USE AS ANTITUMOUR AGENTS CANCER RESEARCH VENTURES LIMITED (GB) 2001-03-01 WO disclosed
WO-2001012603-A1 INDOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR MEDICINAL APPLICATION VERNALIS RESEARCH LIMITED (GB) 2001-02-22 WO disclosed
US-4935420-A MICROBIOCIDES, ANTISEPTICS OTSUKA PHARMACEUTICAL COMPANY, LTD. (JP) 1990-06-19 US disclosed
US-4880806-A BACTERICIDES OTSUKA PHARMACEUTICAL COMPANY, LIMITED (JP) 1989-11-14 US disclosed
US-4874764-A ANTIMICROBIALS OTSUKA PHARMACEUTICAL COMPANY, LIMITED (JP) 1989-10-17 US disclosed
US-4855292-A ANTIMICROBIAL AGENTS OTSUKA PHARMACEUTICAL COMPANY, LIMITED (JP) 1989-08-08 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12509431-B2 1,4-dihydroquinazolinone compounds and uses thereof TNNT2, TNNI3, TNNC1 ALDH1A1 716/4885MAPT 4455/4885POLB 2452/4885
US-20250154111-A1 1,4-DIHYDROQUINAZOLINONE COMPOUNDS AND USES THEREOF TNNI3, TNNT2, SDHA ALDH1A1 780/4885MAPT 3072/4885POLB 4280/4885
US-20240376120-A1 CAMPTOTHECIN COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF WEE1, WASF2, LITAF ALDH1A1 795/4885MAPT 4266/4885POLB 1276/4885
US-20250361213-A1 1,4-DIHYDROQUINAZOLINONE COMPOUNDS AND USES THEREOF TNNI3, TNNT2, SDHA ALDH1A1 780/4885MAPT 3072/4885POLB 4280/4885
US-20250171431-A1 HETEROCYCLIC INHIBITORS OF IGF-1R FOR TREATMENT OF DISEASE IGF1R, TRHR, TSHR ALDH1A1 1694/4885MAPT 3496/4885POLB 3819/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.