SCHEMBL25410957

SCHEMBL25410957

C=Cc1nc(OC2CCC3(CC2)CN(C(=O)O)C3)ccc1C(F)F

nearest known ligand 0.31

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
▸ FFAR4 Q5NUL3 1/20 0.31
▸ ACACB O00763 2/20 0.30
▸ FAAH O00519 1/20 0.30
▸ MGLL Q99685 1/20 0.30
▸ ABHD6 Q9BV23 1/20 0.30
▸ BTK Q06187 1/20 0.30
▸ KRAS P01116 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29426971 0.87 GPR119 (0.40) ACACBFAAHMGLLABHD6
SCHEMBL26631457 0.87 GPR119 (0.40) ACACBFAAHMGLLABHD6
SCHEMBL26631355 0.85 FFAR4 (0.32) FFAR4ACACBFAAHMGLLABHD6
SCHEMBL30503578 0.82 HCRTR1 (0.31) FFAR4FAAHMGLLABHD6
SCHEMBL25434328 0.82 ACACB (0.34) FFAR4ACACBFAAHMGLLABHD6
SCHEMBL26631337 0.82 HCRTR1 (0.31) FFAR4FAAHMGLLABHD6
SCHEMBL30503570 0.81 — —
SCHEMBL30503535 0.78 DGAT1 (0.32) ACACBFAAHMGLLABHD6
SCHEMBL25411360 0.78 DGAT1 (0.32) ACACBFAAHMGLLABHD6
SCHEMBL26631338 0.76 ACACB (0.34) ACACBFAAHMGLLABHD6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11802111-B2 Cyclobutyl amide monoacylglycerol lipase modulators JANSSEN PHARMACEUTICA NV (BE) 2023-10-31 — — US disclosed
EP-4217062-A1 CYCLOBUTYL AMIDE MONOACYLGLYCEROL LIPASE MODULATORS JANSSEN Pharmaceutica NV (BE) 2023-08-02 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11802111-B2 Cyclobutyl amide monoacylglycerol lipase modulators MGLL, LPL, PNLIP FFAR4 125/4885ACACB 60/4885FAAH 8/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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