Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | MMP9 | P14780 | 1/20 | 0.48 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.46 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.46 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.46 |
| ▸ | SLC15A1 | P46059 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | CASP1 | P29466 | 2/20 | 0.44 |
| ▸ | CCR6 | P51684 | 1/20 | 0.44 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | CDC25B | P30305 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27671960 | 0.91 | TRPM8 (0.50) | ALDH1A1MAPK1L3MBTL1MMP9ITGA4 | |
| SCHEMBL2171165 | 0.91 | TRPM8 (0.50) | ALDH1A1MAPK1L3MBTL1MMP9ITGA4 | |
| SCHEMBL14655691 | 0.91 | ALDH1A1 (0.51) | ALDH1A1MAPK1L3MBTL1MMP9TRPM8 | |
| SCHEMBL28777999 | 0.91 | ALDH1A1 (0.51) | ALDH1A1MAPK1L3MBTL1MMP9TRPM8 | |
| SCHEMBL14655692 | 0.91 | ALDH1A1 (0.51) | ALDH1A1MAPK1L3MBTL1MMP9TRPM8 | |
| SCHEMBL22621251 | 0.90 | MGLL (0.48) | ALDH1A1MAPK1L3MBTL1MMP9ITGA4 | |
| SCHEMBL22398803 | 0.90 | MGLL (0.48) | ALDH1A1MAPK1L3MBTL1MMP9ITGA4 | |
| SCHEMBL28406623 | 0.89 | CASP1 (0.50) | ALDH1A1ITGA4ITGB7TRPM8MAPT | |
| SCHEMBL26130291 | 0.89 | CASP1 (0.50) | ALDH1A1ITGA4ITGB7TRPM8MAPT | |
| SCHEMBL19511851 | 0.88 | ALDH1A1 (0.51) | ALDH1A1MAPK1L3MBTL1MMP9SLC15A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8044103-B2 | Cyclic dipeptides and azetidinone compounds and their use in treating CNS injury and neurodegenerative disorders | GEORGETOWN UNIVERSITY (US) | 2011-10-25 | — | — | US | disclosed |
| US-20070161640-A1 | Cyclic dipeptides and azetidinone compounds and their use in treating CNS injury and neurodegenerative disorders | KOZIKOWSKI ALAN P | 2007-07-12 | — | — | US | disclosed |
| US-7202279-B1 | Cyclic dipeptides and azetidinone compounds and their use in treating CNS injury and neurodegenerative disorders | GEORGETOWN UNIVERSITY (US) | 2007-04-10 | — | — | US | disclosed |
| EP-1061936-A4 | CYCLIC DIPEPTIDES AND AZETIDINONE COMPOUNDS AND THEIR USE IN TREATING CNS INJURY AND NEURODEGENERATIVE DISORDERS | UNIV GEORGETOWN (US) | 2005-03-09 | — | — | EP | disclosed |
| EP-1061936-A1 | CYCLIC DIPEPTIDES AND AZETIDINONE COMPOUNDS AND THEIR USE IN TREATING CNS INJURY AND NEURODEGENERATIVE DISORDERS | GEORGETOWN UNIVERSITY (US) | 2000-12-27 | — | — | EP | disclosed |
| WO-1999040931-A1 | CYCLIC DIPEPTIDES AND AZETIDINONE COMPOUNDS AND THEIR USE IN TREATING CNS INJURY AND NEURODEGENERATIVE DISORDERS | GEORGETOWN UNIVERSITY (US) | 1999-08-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070161640-A1 | Cyclic dipeptides and azetidinone compounds and their use in treating CNS injury and neurodegenerative disorders | BDNF, PMP22, ADAM17 | ALDH1A1 3513/4885MAPK1 1375/4885L3MBTL1 2750/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.