Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | DHODH | Q02127 | 11/20 | 0.43 |
| ▸ | PTGFR | P43088 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25439559 | 0.89 | GAA (0.47) | PDE10ATSHRDHODHPTGFRMEN1 | |
| SCHEMBL25438115 | 0.73 | ALDH1A1 (0.45) | PDE10ATSHRDHODHPTGFRALDH1A1 | |
| SCHEMBL25439558 | 0.69 | BRD4 (0.44) | DHODHMEN1KMT2AALDH1A1HPGD | |
| SCHEMBL13780199 | 0.68 | TSHR (0.53) | PDE10ATSHRDHODHMEN1KMT2A | |
| SCHEMBL4382163 | 0.68 | RAB9A (0.49) | PDE10ATSHRDHODHMEN1KMT2A | |
| SCHEMBL27743607 | 0.68 | DHODH (0.44) | TSHRDHODHPTGFRMEN1KMT2A | |
| SCHEMBL6016352 | 0.67 | ADORA3 (0.48) | PDE10ATSHRDHODHMEN1KMT2A | |
| SCHEMBL25437332 | 0.67 | MEN1 (0.48) | PDE10ATSHRDHODHMEN1KMT2A | |
| SCHEMBL5532405 | 0.66 | ALDH1A1 (0.54) | PDE10ATSHRDHODHMEN1KMT2A | |
| SCHEMBL11376424 | 0.66 | PIN1 (0.45) | PDE10ATSHRDHODHALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023134708-A1 | THIAZOLOPYRIDYL AMIDE DERIVATIVES AS DNA POLYMERASE THETA INHIBITORS | BEIGENE , LTD. (KY) | 2023-07-20 | — | — | WO | disclosed |