Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | DHODH | Q02127 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | IKBKB | O14920 | 1/20 | 0.38 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25438115 | 0.89 | ALDH1A1 (0.45) | KDM4EALDH1A1GAADHODHHPGD | |
| SCHEMBL25437330 | 0.76 | ALDH1A1 (0.44) | BRD4KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL25439559 | 0.75 | GAA (0.47) | BRD4KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL29002505 | 0.71 | KDM4E (0.53) | BRD4KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL30499579 | 0.70 | IKBKB (0.63) | KDM4EALDH1A1MEN1KMT2AGAA | |
| SCHEMBL327089 | 0.70 | IKBKB (0.63) | KDM4EALDH1A1MEN1KMT2AGAA | |
| SCHEMBL16102708 | 0.69 | EDNRA (0.48) | BRD4CA1CA2JAK2BCAT2 | |
| SCHEMBL25438118 | 0.69 | PDE10A (0.46) | ALDH1A1MEN1KMT2ADHODHHPGD | |
| SCHEMBL364343 | 0.68 | BCAT2 (0.56) | KDM4EALDH1A1CA1CA2CA9 | |
| Hydrochloric Acid SCHEMBL27374126 | 0.67 | BCAT2 (0.54) | KDM4EALDH1A1CA1CA2CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023134708-A1 | THIAZOLOPYRIDYL AMIDE DERIVATIVES AS DNA POLYMERASE THETA INHIBITORS | BEIGENE , LTD. (KY) | 2023-07-20 | — | — | WO | disclosed |