Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPAR3 | Q9UBY5 | 3/20 | 0.50 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.50 |
| ▸ | TRPM8 | Q7Z2W7 | 10/20 | 0.48 |
| ▸ | FAAH | O00519 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Potassium Ion SCHEMBL23037450 | 0.97 | LPAR3 (0.54) | LPAR3LPAR2TRPM8FAAH | |
| Potassium Ion SCHEMBL2686259 | 0.97 | LPAR3 (0.54) | LPAR3LPAR2TRPM8FAAH | |
| Potassium Ion SCHEMBL7125450 | 0.97 | LPAR3 (0.54) | LPAR3LPAR2TRPM8FAAH | |
| SCHEMBL28675308 | 0.94 | LPAR3 (0.50) | LPAR3LPAR2TRPM8FAAH | |
| Lithium Ion SCHEMBL2543702 | 0.94 | LPAR3 (0.50) | LPAR3LPAR2TRPM8FAAH | |
| SCHEMBL28493992 | 0.94 | LPAR3 (0.50) | LPAR3LPAR2TRPM8FAAH | |
| SCHEMBL2544026 | 0.94 | LPAR3 (0.50) | LPAR3LPAR2TRPM8FAAH | |
| SCHEMBL20139441 | 0.94 | LPAR3 (0.50) | LPAR3LPAR2TRPM8FAAH | |
| SCHEMBL2545037 | 0.94 | LPAR3 (0.50) | LPAR3LPAR2TRPM8FAAH | |
| SCHEMBL29702383 | 0.94 | LPAR3 (0.50) | LPAR3LPAR2TRPM8FAAH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8288497-B2 | Synthesis of poly-(P-aryleneethynylene)s in neat water under aerobic conditions | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2012-10-16 | — | — | US | disclosed |
| US-20110257356-A1 | Synthesis of Poly-(P-Aryleneethynylene)s in Neat Water Under Aerobic Conditions | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2011-10-20 | — | — | US | disclosed |
| US-20090326150-A1 | SYNTHESIS OF POLY-(P-ARYLENEETHYNYLENE)S IN NEAT WATER UNDER AEROBIC CONDIT | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2009-12-31 | — | — | US | disclosed |